ArticleNature structural & molecular biology2024
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Open access · greenAbstract read
In one paragraph
Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacological reviews · 2026Review
- Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction.PLoS biology · 2026Article
- GPR161 contributes to macrophage glycolytic reprogramming via targeting C5aR1 in acute lung injury.Cellular & molecular biology letters · 2026Article
- Light- and chemical-induced ciliary signaling governs dorsal/ventral regionalization of human telencephalic organoids.Nature communications · 2026Article
- Oncogenic GPR161 Drives Melanoma Proliferation and Metabolic Activity through TXNIP Inhibition.Journal of microbiology and biotechnology · 2026Article
- Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives.Molecular pharmacology · 2026Review
- Integrated Analysis of ATAC-Seq and RNA-Seq Reveals the Signal Transduction Regulation of the Molting Cycle in the Muscle of Chinese Mitten Crab (Biomolecules · 2026Article
- GPR161-GLI3 repressor signaling at cilia directs apical constriction and cell fate during cranial neural tube closure.Development (Cambridge, England) · 2025Article
- Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode.Cell research · 2025Article
- Advances in ciliary proteomics - towards cracking the hidden proteome code of cilia.Journal of cell science · 2025Review
- Identification of novel interacting proteins of FUZ and GPR161.bioRxiv : the preprint server for biology · 2025Article
- Transcriptional Consequences of MeCP2 Knockdown and Overexpression in Mouse Primary Cortical Neurons.International journal of molecular sciences · 2025Article
- Constitutively active orphan G protein-coupled receptors through the lenses of cryo-electron microscopy.The Journal of biological chemistry · 2025Review
- GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration.Science advances · 2025Article
- G Protein-Coupled Receptor Signal Intersection at the Primary Cilium.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Structural insight into the self-activation and G-protein coupling of P2Y2 receptor.Cell discovery · 2025Article
- Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia.PLoS biology · 2025Article
- GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.Journal of experimental & clinical cancer research : CR · 2025Article
- A defined tubby domain β-barrel surface region of TULP3 mediates ciliary trafficking of diverse cargoes.Molecular biology of the cell · 2025Article
- Structural basis of frizzled 7 activation and allosteric regulation.Nature communications · 2024Article
Corrections and comments
- Update of
Authors and funding
19 authors at 7 institutions in 2 countries.
Nicholas Hoppe *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Simone Harrison *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Sun-Hee Hwang *Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ziwei ChenDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.
Masha KarelinaBiophysics Program, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1880-4536
Ishan DeshpandeDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Carl-Mikael SuomivuoriDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Vivek R PalicharlaDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Samuel P BerryDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3480-5988
Philipp TschaiknerInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.
Dominik RegeleInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.
Douglas F CoveyDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-9316-8683
Eduard StefanInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-3650-4713
Debora S MarksDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9388-2281
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Ron O DrorBiophysics Program, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6418-2793
Alex S EversDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-0342-0575
Saikat MukhopadhyayDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. saikat.mukhopadhyay@utsouthwestern.edu.ORCID http://orcid.org/0000-0003-4790-3090
Aashish ManglikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. aashish.manglik@ucsf.edu.ORCID http://orcid.org/0000-0002-7173-3741
University of California, San Francisco · USStanford University · USUniversität Innsbruck · ATWashington University in St. Louis · USHarvard University · USThe University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US
Funding
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MMOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6MNeuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2MHedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0MMOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0MUnderstanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0MNeurosteroid and Cholesterol Binding to Integral Membrane ProteinsR35GM149287 · NIGMS · WASHINGTON UNIVERSITY · PI ALEX S. EVERS · 2023 to 2026
$2.4MTransition zone control of ciliary signalingR01DE029454 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F · 2019 to 2022
$2.3MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MGlacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8MMolecular Biophysics Training GrantT32GM149436 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik · 2023 to 2026
$1.6MSignaling at the primary cilium in development and diseaseR35GM144136 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Saikat Mukhopadhyay · 2022 to 2026
$1.6MNIAMS NIH HHS R01 AR054396NICHD NIH HHS R01 HD089918NIDCR NIH HHS R01 DE029454NIGMS NIH HHS R01 GM108799NIGMS NIH HHS R01 GM138992NIGMS NIH HHS R35 GM144136NIGMS NIH HHS R35 GM149287NIGMS NIH HHS T32 GM008313NIGMS NIH HHS T32 GM149436NIGMS NIH HHS U24 GM129541NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881NIMH NIH HHS P50 MH122379
Abstract
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated remains unclear. Here, we determined a cryogenic-electron microscopy structure of active human GPR161 bound to heterotrimeric G
Indexed as
Hedgehog ProteinsSignal TransductionCiliaHumansMutationReceptors, G-Protein-CoupledHedgehog ProteinsReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.