ArticleNature2024
Circulating myeloid-derived MMP8 in stress susceptibility and depression.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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0cells of the map it votes in
97citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
97 citing papers in PubMed, 135 citations in OpenAlex.
- Immune-related biomarkers for major depressive disorder identified via integrated bioinformatics and machine learning.European journal of psychotraumatology · 2026Review
- The dual role of arginine vasopressin in immune regulation: Balancing immunostimulation and immunosuppression.Brain, behavior, & immunity - health · 2026Review
- Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.Brain, behavior, & immunity - health · 2026Review
- Reframing stress adaptation as a dynamic system failure along a threat-response continuum: towards a phase-specific, mechanism-driven framework.Molecular psychiatry · 2026Article
- GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice.Acta pharmacologica Sinica · 2026Article
- Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.Molecular psychiatry · 2026Article
- Neuroimmune interactions: from molecular mechanisms to therapeutic targets.Molecular biomedicine · 2026Review
- Single-cell transcriptomics provides insights into the stress-immune interplay and informs disease risk.Cell genomics · 2026Article
- Potential Shared Immunometabolic Signatures Between Familial Hypercholesterolemia and Major Depressive Disorder: Integrative Transcriptomic Analysis, Mendelian Randomization, and Clinical Validation.International journal of molecular sciences · 2026Article
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity.Molecular psychiatry · 2026Article
- Standardized chronic restraint stress protocols reveal dynamic evolution of behavioral adaptations in male mice: implications for translational neuroscience.Molecular psychiatry · 2026Article
- Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk.Molecular psychiatry · 2026Article
- Peri-implant crevicular fluid stress-related biomarkers and psychometric scores in peri-implant health and disease.Clinical oral investigations · 2026Article
- Aspirin alleviates long-term high-fat diet-induced depressive-like behavior in male mice via suppressing arachidonic acid-mediated microglial activation and neuroinflammation.Molecular psychiatry · 2026Article
- Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signaling.bioRxiv : the preprint server for biology · 2026Article
- Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.Translational psychiatry · 2026Review
- Exosomes derived from M1-macrophage promote enteric neuronal injury via MMP8-TGF-β pathway.Journal of advanced research · 2026Article
- Psychological stress during medical internship is associated with inflammatory signatures linked to mental health.Brain, behavior, & immunity - health · 2026Article
- CEBPD-MMP8 Axis Contributes to Cardiomyocyte Injury in Septic Shock.Applied biochemistry and biotechnology · 2026Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 6 institutions in 3 countries.
Flurin CathomasNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Flurin.Cathomas@mssm.edu.ORCID 0000-0002-8274-1317
Hsiao-Yun Lin *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kenny L Chan *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3101-1792
Long Li *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1354-8468
Lyonna F Parise *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7527-8977
Johana Alvarez *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Romain Durand-de CuttoliNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0240-7608
Antonio V AubryNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Samer MuharebNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0007-8401-4010
Fiona DeslandDepartment of Oncological Sciences, Marc and Jennifer Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yusuke ShimoNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aarthi RamakrishnanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Molly EstillNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen Ferrer-PérezNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric M PariseNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5364-5820
C Matthias WilkDepartment of Oncological Sciences, Marc and Jennifer Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manuella P KasterDepartment of Biochemistry, Federal University of Santa Catarina, Santa Catarina, Brazil.ORCID 0000-0003-0258-6204
Jun WangNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4291-2134
Allison SowaMicroscopy CoRE and Advanced Bioimaging Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
William G JanssenBrain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sara CostiDepression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine of Mount Sinai, New York, NY, USA.
Adeeb RahmanDepartment of Oncological Sciences, Marc and Jennifer Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicolas FernandezDepartment of Oncological Sciences, Marc and Jennifer Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew CampbellSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
Eric J NestlerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7905-2000
Li ShenNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5190-2851
Miriam MeradDepartment of Oncological Sciences, Marc and Jennifer Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4481-7827
James W MurroughNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6286-1242
Scott J RussoNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Scott.Russo@mssm.edu.ORCID 0000-0002-6470-1805
Allen Institute for Brain Science · USTisch Hospital · USCenter for Discovery · USIcahn School of Medicine at Mount Sinai · USTrinity College Dublin · IEUniversidade Federal de Santa Catarina · BR
Funding
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Abraham Teunissen · 2017 to 2026
$24.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MUsing neuroeconomics to disentangle the transcriptional mechanisms underlying resilience versus susceptibility to stressR01MH051399 · NIMH · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1994 to 2023
$10.2MROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2MNeural Circuit Mechanisms of Stress-Impaired Social RewardR01MH127820 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2021 to 2025
$3.5MEpigenetic Mechanisms of Chronic Stress ActionR01MH129306 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ERIC J. NESTLER · 2023 to 2026
$2.7MRole of lateral habenula orexin receptor signaling in aggressive social behaviorR01MH114882 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2017 to 2021
$2.7MSex Differences in Neural Circuit Mechanisms of AggressionR01MH133299 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2023 to 2026
$2.6MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MFunctions of the Cortical Amygdala in social behaviorK99DA058213 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AUBRY, ANTONIO V · 2023 to 2024
$274kBrain-gut interactions regulating stress-related gut inflammation and barrier permeabilityK99DK137037 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHAN, KENNY · 2023 to 2024
$182kNHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL142494NIDA NIH HHS K99 DA058213NIDDK NIH HHS K99 DK137037NIH HHS S10 OD026880NIH HHS S10 OD030463NIMH NIH HHS R01 MH051399NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH114882NIMH NIH HHS R01 MH127820NIMH NIH HHS R01 MH129306NIMH NIH HHS R01 MH133299
Abstract
Psychosocial stress has profound effects on the body, including the immune system and the brain
Indexed as
Major Depressive DisorderMatrix Metalloproteinase 8MonocytesStress, PsychologicalAnimalsExtracellular SpaceHumansMiceMice, Inbred C57BLNucleus AccumbensParenchymal TissueSingle-Cell Gene Expression AnalysisSocial BehaviorSocial IsolationMatrix Metalloproteinase 8MMP8 protein, humanMMP8 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.