ArticleNature2024
Allosteric modulation and G-protein selectivity of the Ca
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 54 citations in OpenAlex.
- Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.Nature communications · 2026Article
- Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.Nature communications · 2026Article
- Structural Evolution of Hydrated Alkaline-Earth Metal Ion Clusters via Molecular Face Theory with Kohn-Sham One-Electron Potential.ACS omega · 2026Article
- G protein selectivity in group I metabotropic glutamate receptors.Science advances · 2026Article
- Polyamines in CNS malignancies: positively charged culprits in the hijacking of neural and immune signaling pathways.Amino acids · 2026Review
- Exploring multiple drug actions of a CaNaunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Subtype-dependent arrestin engagement of the metabotropic glutamate receptors.Nature communications · 2026Article
- Structural and Energetic Determinants of Sweet Protein Recognition: Mechanistic Insights into Thaumatin Binding to the Human T1R2/T1R3 Receptor.International journal of molecular sciences · 2026Article
- Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.Drug delivery and translational research · 2026Article
- CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Nature communications · 2026Article
- pFastBac4x: A Novel Vector for the Simultaneous Expression of Four Proteins-Expression and Purification of a G-Protein Complex as a Case Study.Molecular biotechnology · 2026Article
- Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HTNature communications · 2026Article
- The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Review
- A novel gain-of-function mutation (W818R) of calcium-sensing receptor in a family with autosomal dominant hypocalcemia type 1.Frontiers in endocrinology · 2026Article
- Activation of CaExperimental brain research · 2025Article
- Article
- The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.Molecular pharmacology · 2025Article
- Calcium-sensing receptor: a potential target for liver health and diseases.Journal of translational medicine · 2025Review
- Structural Basis of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Feng He *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6286-8134
Cheng-Guo Wu *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Yang Gao *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8758-0954
Sabrina N Rahman *Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2131-866X
Magda ZaoralováDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0000-5710-9419
Makaía M Papasergi-ScottDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3238-3213
Ting-Jia GuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-8359-0653
Michael J RobertsonDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2610-680X
Alpay B SevenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-0056-3869
Jesper M MathiesenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4251-4416
Georgios SkiniotisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.ORCID 0000-0003-0238-7846
Stanford University · USUniversity of Copenhagen · DKUniversity of Wisconsin–Madison · USSir Run Run Shaw Hospital · CNStanford Medicine · US
Funding
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7MStructural Basis of Signal Instigation Through Family C GPCRsR01NS122394 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SKINIOTIS, GEORGIOS · 2021 to 2025
$3.4MMechanistic Basis of Calcium Sensing Receptor SignalingR01DK132902 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Georgios Skiniotis · 2022 to 2026
$3.1MAcquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1MNCRR NIH HHS S10 RR029531NIDDK NIH HHS R01 DK071801NIDDK NIH HHS R01 DK132902NINDS NIH HHS R01 NS122394
Abstract
The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor
Indexed as
Heterotrimeric GTP-Binding ProteinsReceptors, Calcium-SensingAllosteric RegulationCalciumCinacalcetCryoelectron MicroscopyGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11HumansLigandsLipidsNanostructuresPolyaminesProtein ConformationSubstrate SpecificityTryptophanCalciumCASR protein, humanCinacalcetGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11Heterotrimeric GTP-Binding ProteinsLigandsLipidsPolyaminesReceptors, Calcium-SensingTryptophan
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.