ArticleNature2024
Convergence of coronary artery disease genes onto endothelial cell programs.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
32.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus.Nature communications · 2025Pooled it
- Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.Biochemistry and biophysics reports · 2026Article
- Article
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- Machine Learning Reveals the Contribution of Rare Genetic Variants and Enhances Risk Prediction for Coronary Artery Disease in the Japanese Population.Circulation. Genomic and precision medicine · 2026Article
- From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation.Biomolecules · 2026Review
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.Cell genomics · 2026Article
- Region-Level Design and Analysis of CRISPR Perturbation Screens with FRACTEL.bioRxiv : the preprint server for biology · 2026Article
- Cardiovascular Genetic Epidemiology in the Genome-Wide Era: From Association Discovery to Mechanistic Dissection and Clinical Translation.Cardiovascular drugs and therapy · 2026Review
- Causal effect estimation from trans-regulatory single-cell CRISPR screens.Cell genomics · 2026Review
- Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs.bioRxiv : the preprint server for biology · 2026Article
- Common Coronary Artery Disease Risk Variants in Endothelial Regulatory Elements Modulate Tetraspanin 14 Expression and Notch Signaling.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα.bioRxiv : the preprint server for biology · 2026Article
- Targeted single-cell RNA and perturbation sequencing with TAP-seq.Nature protocols · 2026Review
- Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve.Nature communications · 2026Article
- Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.Cell genomics · 2026Article
- Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits.American journal of human genetics · 2026Article
- Variant-to-gene mapping identifiesbioRxiv : the preprint server for biology · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 4 institutions in 2 countries.
Gavin R Schnitzler *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Helen Kang *Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9522-1911
Shi FangBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramcharan S AngomDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.ORCID 0000-0002-5894-1108
Vivian S Lee-KimBroad Institute of MIT and Harvard, Cambridge, MA, USA.
X Rosa MaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8297-4279
Ronghao ZhouDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Tony ZengDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Katherine GuoDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Martin S TaylorDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1560-9276
Shamsudheen K VellarikkalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Aurelie E BarryBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Oscar Sias-GarciaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Alex BloemendalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Glen MunsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Philine GuckelbergerBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1057-2518
Tung H NguyenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Drew T BergmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-8314-7088
Stephen HinshawDepartment of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Nathan ChengBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Brian ClearyBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0825-7129
Krishna AragamBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-3223-9131
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Hilary K FinucaneBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-3864-9828
Debabrata MukhopadhyayDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA.ORCID 0000-0003-1858-5054
Rajat M GuptaBroad Institute of MIT and Harvard, Cambridge, MA, USA. rgupta@bwh.harvard.edu.ORCID 0000-0001-9865-4106
Jesse M EngreitzBroad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.ORCID 0000-0002-5754-1719
Broad Institute · USStanford University · USJacksonville College · USHarvard University · US
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MStanford Center for Connecting DNA Variants to Function and PhenotypeUM1HG011972 · NHGRI · STANFORD UNIVERSITY · PI JESSE M ENGREITZ, THOMAS QUERTERMOUS · 2021 to 2026
$10.5MTargeting Pancreatic Cancer Using Peptide Chemistry: From Bench to BedsideR01CA150190 · NCI · MAYO CLINIC ROCHESTER · PI MIERKE, DALE F, MUKHOPADHYAY, DEBABRATA · 2010 to 2021
$5.7MDistinct Pathways of VPF/VEGF ReceptorsR01HL070567 · NHLBI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2002 to 2014
$4.7MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MDistinct Pathways of VPF/VEGF ReceptorsR01HL140411 · NHLBI · MAYO CLINIC JACKSONVILLE · PI DEBABRATA MUKHOPADHYAY · 2018 to 2026
$4.0MMapping, modeling, and manipulating 3D contacts in vascular cells to connect risk variants to disease genesR01HL159176 · NHLBI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2022 to 2025
$2.8MA genetic approach to identify the common mechanisms of vascular diseaseDP2HL152423 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, RAJAT M · 2019 to 2022
$2.8MHigh-throughput cellular genetics to connect noncoding variants to coronary artery disease genesR01HL164811 · NHLBI · BROAD INSTITUTE, INC. · PI JESSE M ENGREITZ, RAJAT M GUPTA · 2023 to 2026
$2.7MMapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell typesR35HG011324 · NHGRI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2020 to 2024
$2.3MIdentifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic riskU01HL166060 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, RAJAT M, SEGRE, AYELLET VERED · 2022 to 2025
$2.2MElucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.K08DK129824 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TAYLOR, MARTIN S · 2021 to 2025
$853kNCI NIH HHS R01 CA150190NHGRI NIH HHS K99 HG009917NHGRI NIH HHS R00 HG009917NHGRI NIH HHS R35 HG011324NHGRI NIH HHS T32 HG000044NHGRI NIH HHS UM1 HG011972NHLBI NIH HHS DP2 HL152423NHLBI NIH HHS R01 HL070567NHLBI NIH HHS R01 HL140411NHLBI NIH HHS R01 HL159176NHLBI NIH HHS R01 HL164811NHLBI NIH HHS U01 HL166060NIDDK NIH HHS K08 DK129824NIGMS NIH HHS T32 GM087237
Abstract
Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge
Indexed as
Coronary Artery DiseaseEndothelial CellsGenome-Wide Association StudyHemangioma, Cavernous, Central Nervous SystemCarrier ProteinsEpigenomicsGenetic Predisposition to DiseaseHumansMolecular ChaperonesMultifactorial InheritancePolymorphism, Single NucleotideSignal TransductionCarrier ProteinsCCM2 protein, humanMolecular ChaperonesTLNRD1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.