ArticleNature2024
A distinct cortical code for socially learned threat.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Overlapping representations in the ventral hippocampus support rapid fear memory retrieval.Nature neuroscience · 2026Article
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- Beyond Fear Learning in Isolation: Integration of Social Dimensions into Aversive Learning.Current protocols · 2026Review
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- The global patent landscape of optogenetics: current advances, challenges and opportunities.Nature biotechnology · 2026Article
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- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Integrating optical neuroscience tools into touchscreen operant systems.Nature protocols · 2025Review
- Orbitofrontal cortex influences dopamine dynamics associated with alloparental behavioral acquisition in female mice.Science advances · 2025Article
- Fear Synchrony of Mouse Dyads: Interaction of Sex Composition and Stress.Biological psychiatry global open science · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis.Biological psychiatry · 2025Review
- Layer-specific input to medial prefrontal cortex is linked to stress susceptibility.Translational psychiatry · 2025Article
- The ARCNature communications · 2025Article
- Cortical representations of affective pain shape empathic fear in male mice.Nature communications · 2025Article
- Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.PloS one · 2025Article
- The hippocampal CA2 region discriminates social threat from social safety.Nature neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Shana E Silverstein *Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. Shana.Silverstein@nih.gov.ORCID 0000-0003-0259-4212
Ruairi O'Sullivan *Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Olena Bukalo *Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Dipanwita PatiDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6303-4871
Julia A SchafferLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Aaron LimogesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Leo ZsembikLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.ORCID 0000-0003-2609-5637
Takayuki YoshidaLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
John J O'MalleyUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, NIH, Bethesda, MD, USA.
Ronald F PaletzkiNational Institute of Mental Health, NIH, Bethesda, MD, USA.
Abby G LiebermanLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Mio NonakaLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.ORCID 0000-0002-3492-6659
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9440-3967
Charles R GerfenNational Institute of Mental Health, NIH, Bethesda, MD, USA.ORCID 0000-0001-9008-4882
Mario A PenzoUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, NIH, Bethesda, MD, USA.ORCID 0000-0002-5368-1802
Thomas L KashDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-4747-4495
Andrew HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. Andrew.Holmes@nih.gov.ORCID 0000-0001-7308-1129
National Institute on Alcohol Abuse and Alcoholism · USNational Institute of Mental Health · USUniversity of North Carolina at Chapel Hill · USHoward Hughes Medical Institute · US
Funding
Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7MFunctional Organization Of The Cerebral Cortex and Basal GangliaZIAMH002497 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GERFEN, CHARLES R · 2009 to 2025
$18.3MDissecting the stress circuits of the paraventricular nucleus of the thalamusZIAMH002950 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PENZO, MARIO · 2016 to 2025
$17.5MThe Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6MDetermining the impact of BNST CRF systems on inflammatory pain-induced disruptions of behaviorR01NS122230 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASH, THOMAS L. · 2021 to 2025
$2.0MMouse models of the early life origins of stress disordeZ01AA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2004 to 2008
$1.9MIntramural NIH HHS Z01 AA000411Intramural NIH HHS ZIA MH002497Intramural NIH HHS ZIA MH002950NIAAA NIH HHS R01 AA019454NINDS NIH HHS R01 NS122230
Abstract
Animals can learn about sources of danger while minimizing their own risk by observing how others respond to threats. However, the distinct neural mechanisms by which threats are learned through social observation (known as observational fear learning
Indexed as
CuesFearNeural PathwaysPrefrontal CortexSocial LearningAmygdalaAnimalsCalciumElectrophysiologyFreezing Reaction, CatalepticHippocampusMiceNeuronsOptogeneticsPeriaqueductal GrayPhotic StimulationCalcium
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.