ArticleNature2024
Bile salt hydrolase catalyses formation of amine-conjugated bile acids.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
50.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- Pooled it
- Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure.Nature communications · 2025Trial
- Host diets drive microbiome evolution and functional divergence.Genes & diseases · 2027Review
- The gut microbiome and mitochondrial function in metabolism, immunity, and disease.Gut microbes · 2026Review
- A novel bile salt hydrolase-producingGut microbes · 2026Article
- The gut microbiota and host immunity synergistically orchestrate colonization resistance.Gut microbes · 2026Review
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Bile acid signaling in health and disease.Molecular biomedicine · 2026Review
- Expanding bile acid diversityNatural product reports · 2026Review
- Early-life colonization withScience (New York, N.Y.) · 2026Article
- Genome-Guided Probiotic Mechanisms of Enterococcus hirae SMU2502: Wnt/β-catenin-Driven Intestinal Epithelial Proliferation and Protection Against Salmonella Infection.Probiotics and antimicrobial proteins · 2026Article
- Article
- Impact of alcohol on gut microbial metabolism and the gut-liver-brain axis.Alcohol (Fayetteville, N.Y.) · 2026Review
- The microbiome regulates host metabolic health and diseases through microbial enzymes.Nature reviews. Gastroenterology & hepatology · 2026Review
- Bifidobacterium animalis reshapes the bile acid pool and prevents neonatal jaundice: a clinical microbiome study from correlation to causation.NPJ biofilms and microbiomes · 2026Article
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- Sulfated bile acid produced by a human gut commensal alleviates paediatric sepsis in mice.Nature microbiology · 2026Article
- Microbiota-Derived Metabolites in Developmental Programming: Bridging Early-Life Gut Microbiota to Childhood Metabolic Disorders.Current medical science · 2026Review
- Ecology and engineering to modify the bile acid output of a defined microbial community.bioRxiv : the preprint server for biology · 2026Article
- Glucuronidation metabolomic fingerprinting to map host-microbe metabolism.Nature communications · 2026Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 7 institutions in 2 countries.
Bipin Rimal *Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.
Stephanie L Collins *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-2773-646X
Ceylan E TanesDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Edson R RochaDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Megan A GrandaDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.
Sumeet SolankiDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Nushrat J HoqueDepartment of Chemistry, Pennsylvania State University, University Park, PA, USA.
Emily C GentrySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Imhoi KooHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-5816-0627
Erin R ReillyDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Fuhua HaoDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-0865-5269
Devendra PaudelDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-6521-9121
Vishal SinghDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
Tingting YanLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Min Soo KimDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Joseph P ZackularDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-3228-3055
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Dhimant DesaiDepartment of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA.
Shantu AminDepartment of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA.
James P ColemanDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Yatrik M ShahDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2487-4816
Jordan E BisanzDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-8649-1706
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7990-2140
John P Vanden HeuvelDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.
Gary D WuDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Babette S ZemelDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID 0000-0002-3003-1030
Emily E WeinertDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA. adp117@psu.edu.ORCID 0000-0003-2073-0070
Pennsylvania State University · USChildren's Hospital of Philadelphia · USNational Institutes of Health · USEast Carolina University · USUniversity of California San Diego · USUniversity of Michigan · USUniversity of Pennsylvania · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MXenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4MTranslational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8MControl of iron absorption by intestinal HIF2 in iron and hematological disordersR01DK095201 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2012 to 2025
$5.7MThe role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2MEnvironmental Chemical Impact on the Host-Microbiome InteractionR35ES035027 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Andrew Patterson · 2023 to 2026
$3.6MInfant Growth and Microbiome Study 2R01DK107565 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WU, GARY D., ZEMEL, BABETTE S · 2015 to 2019
$3.6MCollaborative Microbial Metabolite CenterU24DK133658 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2022 to 2026
$2.9MReverse Metabolomics for the Discovery of Disease Associated Microbial MoleculesR01DK136117 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2023 to 2026
$2.9MNCATS NIH HHS UL1 TR001878NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA130810NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA245546NIAID NIH HHS R00 AI147165NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK095201NIDDK NIH HHS R01 DK107565NIDDK NIH HHS R01 DK136117NIDDK NIH HHS T32 DK120509NIDDK NIH HHS U01 DK119702NIDDK NIH HHS U24 DK133658NIEHS NIH HHS R35 ES035027NIGMS NIH HHS R01 GM125842NIGMS NIH HHS R35 GM138369NIGMS NIH HHS R35 GM151045NIGMS NIH HHS T32 GM102057NIH HHS S10 OD021750
Abstract
Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes
Indexed as
AcyltransferasesAmidohydrolasesAminesBile Acids and SaltsBiocatalysisGastrointestinal MicrobiomeBacteroides fragilisCell Culture TechniquesCohort StudiesEscherichia coliHumansInfantLigandsPregnane X ReceptorReceptors, Aryl HydrocarbonTranscription FactorsAcyltransferasesAmidohydrolasesAminesBile Acids and Saltscholoylglycine hydrolaseLigandsPregnane X ReceptorReceptors, Aryl HydrocarbonTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.