Evidence map›Paper›PMID 38326608›Full record

ArticleNature2024

Bile salt hydrolase acyltransferase activity expands bile acid diversity.

Douglas V Guzior, Maxwell Okros, Madison Shivel, Bruin Armwald, Christopher Bridges, Yousi Fu, Christian Martin, Anthony L Schilmiller, Wendy M Miller, Kathryn M Ziegler and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
38.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Irritable bowel syndrome.Nature reviews. Disease primers · 2026
    Review
  7. Expanding bile acid diversityNatural product reports · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Douglas V GuziorDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-7019-3261
Maxwell OkrosDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Madison ShivelDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Bruin ArmwaldDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Christopher BridgesDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.ORCID 0009-0005-6905-559X
Yousi FuDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Christian MartinDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Anthony L SchilmillerMass Spectrometry and Metabolomics Core, Michigan State University, East Lansing, MI, USA.
Wendy M MillerCorewell Health, William Beaumont University Hospital, Royal Oak, MI, USA.
Kathryn M ZieglerCorewell Health, William Beaumont University Hospital, Royal Oak, MI, USA.
Matthew D SimsCorewell Health, William Beaumont University Hospital, Royal Oak, MI, USA.
Michael E MaddensCorewell Health, William Beaumont University Hospital, Royal Oak, MI, USA.
Stewart F GrahamCorewell Health, William Beaumont University Hospital, Royal Oak, MI, USA.
Robert P HausingerDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-3643-2054
Robert A QuinnDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. quinnrob@msu.edu.ORCID 0000-0002-9829-3256
Michigan State University · USOakland University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome because of their antimicrobial properties

Indexed as

AcyltransferasesAmidohydrolasesBile Acids and SaltsClostridium perfringensGastrointestinal MicrobiomeAllelesAmino AcidsAnimalsAnti-Infective AgentsBariatric SurgeryCatalytic DomainFecesGallbladderHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsAcyltransferasesAmidohydrolasesAmino AcidsAnti-Infective AgentsBile Acids and Saltscholoylglycine hydrolaseTaurocholic Acid

Identifiers

PMID38326608
OpenAlexW4391597743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.