ArticleNature microbiology2024
A molecular toolkit of cross-feeding strains for engineering synthetic yeast communities.
Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Principles for Rigorous Design and Application of Synthetic Microbial Communities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Pooled it
- Engineering an asymmetric cross-feeding consortium inSynthetic and systems biotechnology · 2026Article
- The use of multi-species probiotic-derived vesicles to encapsulate luteolin for preventing colitis in a mouse model.iScience · 2026Article
- SynComs should be rigorously defined, not renamed.Nature communications · 2026Article
- A programmable fungal platform for engineered living textiles.Science advances · 2026Article
- Synthetic Microbial Community Biosensors: From Engineered Ecosystems to Modular Detection Platforms with AI-Driven Intelligence.Biosensors · 2026Review
- Programmable cell-cell adhesion in synthetic yeast communities for improved bioproduction.Nature chemical biology · 2026Article
- Microbial Competition and Nutrient Limitation Remodel the Volatilome ofJournal of fungi (Basel, Switzerland) · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- Low initial metabolite production enhances stability in syntrophic bacterial consortia.Communications biology · 2026Article
- Synthetic circuits for cell ratio control.Nature · 2026Article
- Omics Technologies-Driven Research and Applications of Synthetic Biology.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Programmable cell differentiation in budding yeast uncouples reproductive and metabolic tasks.bioRxiv : the preprint server for biology · 2025Article
- A consortium to synthesize lignans.Nature chemical biology · 2025Article
- De novo biosynthesis of plant lignans by synthetic yeast consortia.Nature chemical biology · 2025Article
- From Microbial Switches to Metabolic Sensors: Rewiring the Gut-Brain Kynurenine Circuit.Biomedicines · 2025Review
- Microbial consortia for the conversion of biomass into fuels and chemicals.Nature communications · 2025Review
- Advances in synthetic microbial ecosystems approach for studying ecological interactions and their influencing factors.Engineering microbiology · 2025Review
- COmmunity and Single Microbe Optimisation System (COSMOS).NPJ systems biology and applications · 2025Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Engineered microbial consortia often have enhanced system performance and robustness compared with single-strain biomanufacturing production platforms. However, few tools are available for generating co-cultures of the model and key industrial host Saccharomyces cerevisiae. Here we engineer auxotrophic and overexpression yeast strains that can be used to create co-cultures through exchange of essential metabolites. Using these strains as modules, we engineered two- and three-member consortia using different cross-feeding architectures. Through a combination of ensemble modelling and experimentation, we explored how cellular (for example, metabolite production strength) and environmental (for example, initial population ratio, population density and extracellular supplementation) factors govern population dynamics in these systems. We tested the use of the toolkit in a division of labour biomanufacturing case study and show that it enables enhanced and tuneable antioxidant resveratrol production. We expect this toolkit to become a useful resource for a variety of applications in synthetic ecology and biomanufacturing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.