Evidence map›Paper›PMID 38326534›Full record

ArticleScientific reports2024

Embryo-endometrial interaction associated with the location of the embryo during the mobility phase in mares.

Thadeu de Castro, Machteld van Heule, Rafael R Domingues, Julio C F Jacob, Peter F Daels, Stuart A Meyers, Alan J Conley, Pouya Dini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Thadeu de CastroDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Machteld van HeuleDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Rafael R DominguesDepartment of Animal and Dairy Sciences, The Ohio State University, Columbus, OH, 43210, USA.
Julio C F JacobDepartmento de Reprodução E Avalição Animal, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janiro, 23897-000, Brazil.
Peter F DaelsDepartment of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, University of Ghent, 9820, Merelbeke, Belgium.
Stuart A MeyersDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Alan J ConleyDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Pouya DiniDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA. pdini@ucdavis.edu.
University of California, Davis · USGhent University · BEThe Ohio State University · USUniversidade Federal Rural do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryo-maternal crosstalk is essential to establish pregnancy, with the equine embryo moving throughout the uterus on days 9-15 (ovulation = day 0) as part of this interaction. We hypothesized that the presence of a mobile embryo induces local changes in the gene expression of the endometrium. On Day 12, the endometrial transcripts were compared among three groups: uterine horn with an embryo (P+, n = 7), without an embryo (P-, n = 7) in pregnant mares, and both uterine horns of nonbred mares (NB, n = 6). We identified 1,101 differentially expressed genes (DEGs) between P+ vs. NB and 1,229 DEGs between P- vs. NB. The genes upregulated in both P+ and P- relative to NB were involved in growth factor pathway and fatty acid activation, while downregulated genes were associated with oxytocin signaling pathway and estrogen receptor signaling. Comparing the transcriptome of P+ to that of P-, we found 59 DEGs, of which 30 genes had a higher expression in P+. These genes are associated with regulating vascular growth factors and the immune system, all known to be essential in early pregnancy. Overall, this study suggests that the mobile embryo influences the endometrial gene expression locally.

Indexed as

EndometriumUterusAnimalsEmbryo, MammalianFemaleHorsesOvulationOxytocinPregnancyOxytocin

Identifiers

PMID38326534
PMCPMC10850102
OpenAlexW4391599699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.