Evidence map›Paper›PMID 38326520›Full record

ArticleMolecular neurobiology2024

Desmoglein-2 Affects Vascular Function in Moyamoya Disease by Interacting with MMP-9 and Influencing PI3K Signaling.

Ajun Wang, Nan Li, Nan Zhang, Jian Liu, Tao Yang, Dongxue Li, Changwen Li, Rui Li, Tongcui Jiang, Chengyu Xia

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ajun Wang *Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0009-0007-8282-7659
Nan Li *Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0000-0003-3631-264X
Nan ZhangDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0000-0002-9960-6859
Jian LiuDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0009-0009-7801-8853
Tao YangDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0000-0002-6490-9489
Dongxue LiDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0000-0001-5302-8347
Changwen LiDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0000-0001-9412-9857
Rui LiDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China.ORCID http://orcid.org/0009-0008-3035-0980
Tongcui JiangSchool of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province, China. tongcuij@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-6894-7490
Chengyu XiaDepartment of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui Province, China. xiachengyu@ustc.edu.cn.ORCID http://orcid.org/0000-0002-3703-9879
University of Science and Technology of China · CNAnhui Medical University · CN

Funding

the Key Research and Development Project of Anhui Province 1804h08020250
6 · The paper itself

Abstract

The pathogenesis and development of Moyamoya disease are still unclear. This study aimed to investigate the effect of desmoglein-2 (DSG2) on Moyamoya disease and determine the inhibitory effect of DSG2 in vascular remodeling in Moyamoya disease.RNA sequencing, immunohistochemistry (IHC), and western blotting were used to detect the expression of DSG2 in the superficial temporal artery (STA) tissues of Moyamoya disease. The association between DSG2 and endothelial cells' biological activities was investigated by cell counting kit-8 (CCK-8), migration assay, tube formation assay, flow cytometry with Annexin V-FITC/PI staining, and TUNEL apoptotic cell detection kit. Pathways affected by overexpression or knockdown of DSG2 were identified in endothelial cells.The expression of DSG2 in the STA tissues of Moyamoya disease was lower than that in normal controls. Overexpression of DSG2 inhibits the proliferation and migration but promotes apoptosis in endothelial cells, and low DSG2 levels result in impaired angiogenesis. In addition, there was an interaction between DSG2 and MMP-9, and DSG2 acted through the PI3K signaling in endothelial cells.Our results indicate that DSG2 affects PI3K signaling in vascular endothelial cells, and MMP-9 is involved in DSG2-mediated vascular changes in Moyamoya disease.

Indexed as

ApoptosisCell MovementCell ProliferationDesmoglein 2Matrix Metalloproteinase 9Moyamoya DiseasePhosphatidylinositol 3-KinasesSignal TransductionAdultEndothelial CellsFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMiddle AgedDesmoglein 2DSG2 protein, humanMatrix Metalloproteinase 9MMP9 protein, humanPhosphatidylinositol 3-KinasesApoptosisDSG2HypoxiaMoyamoya diseaseVascular remodeling

Identifiers

PMID38326520
PMCPMC11339177
OpenAlexW4391593349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.