Evidence map›Paper›PMID 38326455›Full record

ArticleScientific reports2024

Altered resting-state functional connectivity in newborns with hypoxic ischemic encephalopathy assessed using high-density functional near-infrared spectroscopy.

Lingkai Tang, Lilian M N Kebaya, Talal Altamimi, Alexandra Kowalczyk, Melab Musabi, Sriya Roychaudhuri, Homa Vahidi, Paige Meyerink, Sandrine de Ribaupierre, Soume Bhattacharya and 3 more

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lingkai TangBiomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.
Lilian M N KebayaNeuroscience, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Talal AltamimiNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Alexandra KowalczykNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Melab MusabiNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Sriya RoychaudhuriNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Homa VahidiNeuroscience, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Paige MeyerinkNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Sandrine de RibaupierreNeuroscience, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Soume BhattacharyaNeonatal-Perinatal Medicine, Schulich Faculty of Medicine and Dentistry, Western University, London, ON, Canada.
Leandro Tristao Abi Ramia de MoraesMedical Imaging, London Health Sciences Centre, Western University, London, ON, Canada.
Keith St LawrenceBiomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.
Emma G DuerdenBiomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada. eduerden@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) results from a lack of oxygen to the brain during the perinatal period. HIE can lead to mortality and various acute and long-term morbidities. Improved bedside monitoring methods are needed to identify biomarkers of brain health. Functional near-infrared spectroscopy (fNIRS) can assess resting-state functional connectivity (RSFC) at the bedside. We acquired resting-state fNIRS data from 21 neonates with HIE (postmenstrual age [PMA] = 39.96), in 19 neonates the scans were acquired post-therapeutic hypothermia (TH), and from 20 term-born healthy newborns (PMA = 39.93). Twelve HIE neonates also underwent resting-state functional magnetic resonance imaging (fMRI) post-TH. RSFC was calculated as correlation coefficients amongst the time courses for fNIRS and fMRI data, respectively. The fNIRS and fMRI RSFC maps were comparable. RSFC patterns were then measured with graph theory metrics and compared between HIE infants and healthy controls. HIE newborns showed significantly increased clustering coefficients, network efficiency and modularity compared to controls. Using a support vector machine algorithm, RSFC features demonstrated good performance in classifying the HIE and healthy newborns in separate groups. Our results indicate the utility of fNIRS-connectivity patterns as potential biomarkers for HIE and fNIRS as a new bedside tool for newborns with HIE.

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainBiomarkersBrainHumansInfantInfant, NewbornMagnetic Resonance ImagingSpectroscopy, Near-InfraredBiomarkers

Identifiers

PMID38326455
PMCPMC10850364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.