Evidence map›Paper›PMID 38326446›Full record

ArticleScientific reports2024

Psychedelics and sexual functioning: a mixed-methods study.

Tommaso Barba, Hannes Kettner, Caterina Radu, Joseph M Peill, Leor Roseman, David J Nutt, David Erritzoe, Robin Carhart-Harris, Bruna Giribaldi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Role and Ethics of Touch and Non-touch in Psychedelic-Assisted Therapy.Current topics in behavioral neurosciences · 2026
    Review
  5. Review
  6. Review
  7. Exploring Psychedelics for Unmet Needs in Women's Reproductive Health.Psychedelic medicine (New Rochelle, N.Y.) · 2025
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tommaso Barba *Department of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK. tommaso.barba20@imperial.ac.uk.ORCID 0000-0003-2565-4628
Hannes Kettner *Department of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
Caterina RaduDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
Joseph M PeillDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
Leor RosemanDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
David J NuttDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
David ErritzoeDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.ORCID 0000-0002-7022-6211
Robin Carhart-HarrisDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
Bruna GiribaldiDepartment of Medicine, Centre for Psychedelic Research, Imperial College London, London, UK.
Imperial College London · GBUniversity of California, San Francisco · USNIHR Imperial Biomedical Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Do psychedelics affect sexual functioning postacutely? Anecdotal and qualitative evidence suggests they do, but this has never been formally tested. While sexual functioning and satisfaction are generally regarded as an important aspect of human wellbeing, sexual dysfunction is a common symptom of mental health disorders. It is also a common side effect of selective serotonin reuptake inhibitors (SSRIs), a first line treatment for depression. The aim of the present paper was to investigate the post-acute effects of psychedelics on self-reported sexual functioning, combining data from two independent studies, one large and naturalistic and the other a smaller but controlled clinical trial. Naturalistic use of psychedelics was associated with improvements in several facets of sexual functioning and satisfaction, including improved pleasure and communication during sex, satisfaction with one's partner and physical appearance. Convergent results were found in a controlled trial of psilocybin therapy versus an SSRI, escitalopram, for depression. In this trial, patients treated with psilocybin reported positive changes in sexual functioning after treatment, while patients treated with escitalopram did not. Despite focusing on different populations and settings, this is the first research study to quantitively investigate the effects of psychedelics on sexual functioning. Results imply a potential positive effect on post-acute sexual functioning and highlight the need for more research on this.

Indexed as

HallucinogensEscitalopramHumansPsilocybinSelective Serotonin Reuptake InhibitorsSexual BehaviorEscitalopramHallucinogensPsilocybinSelective Serotonin Reuptake Inhibitors

Identifiers

PMID38326446
PMCPMC10850066
OpenAlexW4391630740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.