Evidence map›Paper›PMID 38326340›Full record

ArticleNPJ vaccines2024

Potent induction of humoral and cellular immunity after bivalent BA.4/5 mRNA vaccination in dialysis patients.

Saskia Bronder, Janine Mihm, Rebecca Urschel, Verena Klemis, Tina Schmidt, Stefanie Marx, Amina Abu-Omar, Franziska Hielscher, Candida Guckelmus, Marek Widera and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saskia BronderDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0001-5863-1268
Janine MihmSHG Kliniken, Völklingen, Germany.
Rebecca UrschelDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Verena KlemisDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Tina SchmidtDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0001-7929-5283
Stefanie MarxDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Amina Abu-OmarDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Franziska HielscherDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Candida GuckelmusDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
Marek WideraInstitute for Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-5417-9307
Urban SesterSHG Kliniken, Völklingen, Germany.
Martina SesterDepartment of Transplant and Infection Immunology, Saarland University, Homburg, Germany. martina.sester@uks.eu.ORCID http://orcid.org/0000-0001-5482-0002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knowledge on immunogenicity of the bivalent Omicron BA.4/5 vaccine in dialysis patients and the effect of a previous infection is limited. Therefore, vaccine-induced humoral and cellular immunity was analyzed in dialysis patients and immunocompetent controls with and without prior infection. In an observational study, 33 dialysis patients and 58 controls matched for age, sex and prior infection status were recruited. Specific IgG, neutralizing antibody activity and cellular immunity towards the spike-antigen from parental SARS-CoV-2 and Omicron-subvariants BA.1, BA.2 and BA.4/5 were analyzed before and 13-18 days after vaccination. The bivalent vaccine led to a significant induction of IgG, neutralizing titers, and specific CD4

Identifiers

PMID38326340
PMCPMC10850212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.