ArticleNature communications2024
Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Signaling pathways in Drosophila testis niche: Local signals that regulate stem cell fate.Insect science · 2026Review
- Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plasticity and stringency: rethinking stem cell division modes.Biochemical Society transactions · 2026Review
- Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells.bioRxiv : the preprint server for biology · 2025Article
- Detection of dedifferentiated stem cells in theiScience · 2025Article
- Ovarian germline stem cell dedifferentiation is cytoneme dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025Review
- Shaping and interpretation of Dpp morphogen gradient by endocytic trafficking.PLoS genetics · 2025Article
- Soma-to-germline BMP signal is essential for Drosophila spermiogenesis.Developmental biology · 2025Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Drosophila male germline stem cells (GSCs) reside at the tip of the testis and surround a cluster of niche cells. Decapentaplegic (Dpp) is one of the well-established ligands and has a major role in maintaining stem cells located in close proximity. However, the existence and the role of the diffusible fraction of Dpp outside of the niche have been unclear. Here, using genetically-encoded nanobodies called Morphotraps, we physically block Dpp diffusion without interfering with niche-stem cell signaling and find that a diffusible fraction of Dpp is required to ensure differentiation of GSC daughter cells, opposite of its role in maintenance of GSC in the niche. Our work provides an example in which a soluble niche ligand induces opposed cellular responses in stem cells versus in differentiating descendants to ensure spatial control of the niche. This may be a common mechanism to regulate tissue homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.