GuidelineJournal of the American Dental Association (1939)2024
Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh, and the University of Pennsylvania.
Guideline in Journal of the American Dental Association (1939), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Evidence-based clinical practice guidelines for the management of acute dental pain.The American journal of emergency medicine · 2025Guideline
- Pharmacological Postoperative Pain Management for Paediatric Dental Extractions Under General Anaesthesia: A Systematic Review.Pain research & management · 2025Pooled it
- The effect of Kinesio taping on postoperative complications following mandibular third molar surgery/extraction: a systematic review and meta-analysis of randomized controlled trials.Frontiers in dental medicine · 2025Pooled it
- Effect of photobiomodulation therapy on wound healing and post-extraction pain management of primary molars: a randomized controlled clinical trial.BMC oral health · 2026Trial
- [Interpretation of the American Dental Association practice guidelines for the management of acute dental pain with pharmacotherapy (2023-2024) and its clinical implications for China].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- De-Implementing Low-Value Care in Dentistry: The Case for Choosing Wisely Campaigns.Community dentistry and oral epidemiology · 2026Article
- Oral and Maxillofacial Surgeon Accuracy in Anticipating Supplemental Opioid Use Following Third Molar Extraction.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients.JAMA network open · 2026Article
- Opioid prescribing after nonsurgical root canal therapy: Findings from The National Dental Practice-Based Research Network.Journal of the American Dental Association (1939) · 2026Article
- A Descriptive Analysis of Potential Warfarin-NSAID Interactions in Dental Prescribing in Minas Gerais, Brazil, 2011-2021.Healthcare (Basel, Switzerland) · 2026Article
- Opioid Prescribing by US Dentists and Dental Specialists after Continuing Education.JDR clinical and translational research · 2026Article
- International Trends in Dental Opioid Prescriptions.JAMA network open · 2026Article
- Article
- Customized pharmacological approach to acute and post-operative dental pain control in Iran: guideline review and adaptation.BMC oral health · 2026Article
- Article
- Acute Dental Pain Management and Opioids - An Executive Summary of the Clinical Practice Guideline.Journal of the California Dental Association · 2025Article
- High-risk medications in pediatric dentistry: Patterns, outcomes, and clinical implications.Journal of the American Dental Association (1939) · 2025Article
- Prevalence and factors associated with severe pre-operative pain among patients presenting for non-surgical root canal treatment in the national dental PBRN PREDICT endodontic study.Journal of dentistry · 2025Article
- Efficacy of NSAIDs and corticosteroids as premedication for post-endodontic pain management: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
backgroundA panel convened by the American Dental Association Science and Research Institute, the University of Pittsburgh, and the University of Pennsylvania conducted systematic reviews and meta-analyses and formulated evidence-based recommendations for the pharmacologic management of acute dental pain after simple and surgical tooth extraction(s) and for the temporary management (ie, definitive dental treatment not immediately available) of toothache associated with pulp and periapical diseases in adolescents, adults, and older adults. TYPES OF STUDIES REVIEWED: The panel conducted 4 systematic reviews to determine the effect of opioid and nonopioid analgesics, local anesthetics, corticosteroids, and topical anesthetics on acute dental pain. The panel used the Grading of Recommendations, Assessment, Development and Evaluation approach to assess the certainty of the evidence and the Grading of Recommendations, Assessment, Development and Evaluation Evidence-to-Decision Framework to formulate recommendations.
resultsThe panel formulated recommendations and good practice statements using the best available evidence. There is a beneficial net balance favoring the use of nonopioid medications compared with opioid medications. In particular, nonsteroidal anti-inflammatory drugs alone or in combination with acetaminophen likely provide superior pain relief with a more favorable safety profile than opioids. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Nonopioid medications are first-line therapy for managing acute dental pain after tooth extraction(s) and the temporary management of toothache. The use of opioids should be reserved for clinical situations when the first-line therapy is insufficient to reduce pain or there is contraindication of nonsteroidal anti-inflammatory drugs. Clinicians should avoid the routine use of just-in-case prescribing of opioids and should exert extreme caution when prescribing opioids to adolescents and young adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.