Evidence map›Paper›PMID 38325840›Full record

ArticleEnvironmental health and preventive medicine2024

Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study.

Lei Liu, Changfa Wang, Zhongyang Hu, Shuwen Deng, Saiqi Yang, Xiaoling Zhu, Yuling Deng, Yaqin Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health and preventive medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lei LiuHealth Management Center, The Third Xiangya Hospital, Central South University.
Changfa WangGeneral Surgery Department, The Third Xiangya Hospital, Central South University.
Zhongyang HuDepartment of Neurology, The Third Xiangya Hospital, Central South University.
Shuwen DengHealth Management Center, The Third Xiangya Hospital, Central South University.
Saiqi YangHealth Management Center, The Third Xiangya Hospital, Central South University.
Xiaoling ZhuHealth Management Center, The Third Xiangya Hospital, Central South University.
Yuling DengHealth Management Center, The Third Xiangya Hospital, Central South University.
Yaqin WangHealth Management Center, The Third Xiangya Hospital, Central South University.
Third Xiangya Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimRemnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD.

methodsThis study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD.

resultsAfter multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31-1.67 for quintile 2; HR 2.07, 95%CI 1.85-2.33 for quintile 3; HR 2.55, 95%CI 2.27-2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95-6.05 for quintile 2; HR 4.25, 95%CI 2.44-7.40 for quintile 3; HR 6.29, 95%CI 3.59-10.99 for quintile 4), compared with the quintile 1.

conclusionElevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.

Indexed as

Non-alcoholic Fatty Liver DiseaseAdultCholesterolCohort StudiesHumansProportional Hazards ModelsRisk FactorsCholesterolCohort studyCumulative exposureEpidemiologyNonalcoholic fatty liver diseaseRemnant cholesterol

Identifiers

PMID38325840
PMCPMC10853394
OpenAlexW4391548078

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.