Evidence map›Paper›PMID 38325031›Full record

ArticleNeurobiology of aging2024

Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice.

Jake W Willows, Zahra Alshahal, Naeemah M Story, Michele J Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I Stanford, Juan Peng, Peter C Reifsnyder and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jake W WillowsDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Zahra AlshahalDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Naeemah M StoryDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Michele J AlvesDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Pablo VidalDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
Hallie HarrisDepartment of Neurology, The Ohio State University, Columbus, OH, USA.
Rochelle RodrigoDepartment of Neurology, The Ohio State University, Columbus, OH, USA.
Kristin I StanfordDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
Juan PengDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Peter C ReifsnyderThe Jackson Laboratory, Bar Harbor, ME, USA.
David E HarrisonThe Jackson Laboratory, Bar Harbor, ME, USA.
W David ArnoldDepartment of Neurology, The Ohio State University, Columbus, OH, USA.
Kristy L TownsendDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA. Electronic address: kristy.townsend@osumc.edu.

Funding

Interventions That Retard Mammalian AgingU01AG022308 · NIA · JACKSON LABORATORY · PI Ronny Korstanje · 2003 to 2026
$30.5M
BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence.R01AG060542 · NIA · OHIO STATE UNIVERSITY · PI COEN, PAUL MARTIN, STANFORD, KRISTIN I · 2019 to 2023
$3.0M
American Heart Association-American Stroke Association 18CSA34090028-TOWNSENDNIA NIH HHS R01 AG060542NIA NIH HHS U01 AG022308
6 · The paper itself

Abstract

We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were not improved with running wheel activity. Adipose tissue fibrosis, peripheral neuropathy, and loss of neuromuscular junction integrity were consistent phenotypes in older-aged HET3 mice regardless of physical activity, but aspects of these phenotypes were moderated by the SNP% contributions of the founding strains for the HET3 line. Taken together, the genetic contribution of founder strain SNPs moderated age-related phenotypes in skin and muscle innervation and were dependent on biological sex and chronological age. However, there was not a single founder strain (BALB/cJ, C57BL/6J, C3H/HeJ, DBA/2J) that appeared to drive more protection or disease-risk across aging in this mouse line, but genetic diversity in general was more protective.

Indexed as

Mice, Inbred DBAAnimalsMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsPhenotypeSpecies SpecificityAdiposeAgingExerciseFounder StrainHET3NeuromuscularPeripheral NeuropathySNP

Identifiers

PMID38325031
PMCPMC12302652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.