ArticleScience advances2024
Haplotype-phased genome unveils the butylphthalide biosynthesis and homoploid hybrid origin of
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Favorable Systemic Immune-Inflammation Status Enhances the Neuroprotective Effects of Butylphthalide in Ischemic Stroke: A Post Hoc Analysis of BAST Trial.CNS neuroscience & therapeutics · 2026Trial
- Assembly of the complete mitochondrial genome of Ligusticum chuanxiong and its evolutionary implications.BMC genomics · 2026Article
- Evolutionary tuning of a biosynthetic gene cluster drives furanocoumarin accumulation and diversification.Nature communications · 2026Article
- From folklore to explore: integrating genomic and multiomics data forHorticulture research · 2026Article
- In vitro bioactive metabolite production and plant regeneration of medicinal plant Ligusticum chuanxiong Hort.BMC plant biology · 2026Article
- Revisiting the phylogeny of Conioselinum (Apiaceae) by integrating nrDNA, plastomes and morphology evidence.BMC plant biology · 2026Article
- Cadmium Stress Response of ABC Transporters inGenes · 2025Article
- A cell isolation method from Ligusticum chuanxiong Hort. suitable for obtaining high-quality RNA for Smart-seq.Plant methods · 2025Article
- Hybrid fertility and the rarity of homoploid hybrid speciation.AoB PLANTS · 2025Article
- Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica.Communications biology · 2025Article
- E-Nose and HS-SPME-GC-MS unveiling the scent signature ofFrontiers in plant science · 2025Article
- The application of bacteriophage to veterinary and One-Health medicine-a road map.Frontiers in microbiology · 2025Review
- Insights into the Genomic Background of Nine Common Chinese Medicinal Plants by Flow Cytometry and Genome Survey.Plants (Basel, Switzerland) · 2024Article
- Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV).Viruses · 2024Article
- Cytological analysis of flower development, insights into suitable growth area and genomic background: implications for Glehnia littoralis conservation and sustainable utilization.BMC plant biology · 2024Article
- Evaluation of the Pharmaceutical Activities of Chuanxiong, a Key Medicinal Material in Traditional Chinese Medicine.Pharmaceuticals (Basel, Switzerland) · 2024Review
- SynGAP: a synteny-based toolkit for gene structure annotation polishing.Genome biology · 2024Article
- BuyangHuanwu Decoction alleviates Endothelial Cell Apoptosis and Coronary Microvascular Dysfunction via Regulation of the MAPKK4/p38 Signaling Axis.International journal of medical sciences · 2024Article
- LcSAO1, an Unconventional DOXB Clade 2OGD Enzyme fromInternational journal of molecular sciences · 2023Article
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Authors and funding
15 authors at 6 institutions in 1 country.
Bao NieShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0000-0001-6299-9102
Xueqing ChenShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Zhuangwei HouShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0009-0001-6873-3230
Miaoxian GuoShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0009-0004-6399-1910
Cheng LiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0000-0003-4366-6139
Wenkai SunShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Jiaojiao JiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Lanlan ZangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Song YangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0009-0006-4453-0515
Pengxiang FanCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310063, China.ORCID 0000-0002-4560-3783
Wenhao ZhangState Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.ORCID 0000-0003-2708-2221
Hang LiSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0003-3367-6659
Yuzhu TanState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0003-0614-135X
Wei LiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0000-0002-8670-584X
Li WangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.ORCID 0000-0003-2068-7535
Agricultural Genomics Institute at Shenzhen · CNChengdu University of Traditional Chinese Medicine · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CNSun Yat-sen University · CNZhejiang A & F University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Butylphthalide is one of the first-line drugs for ischemic stroke therapy, while no biosynthetic enzyme for butylphthalide has been reported. Here, we present a haplotype-resolved genome of
Indexed as
BenzofuransDrugs, Chinese HerbalLigusticumHaplotypesPlant Breeding3-n-butylphthalideBenzofuransDrugs, Chinese Herbal
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