Evidence map›Paper›PMID 38324570›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids.

Wei-Shao Wei, Anthony Trubiano, Christian Sigl, Stefan Paquay, Hendrik Dietz, Michael F Hagan, Seth Fraden

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Measuring multisubunit mechanics of geometrically programmed colloidal assemblies via cryo-EM multi-body refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Magnetic decoupling as a proofreading strategy for high-yield, time-efficient microscale self-assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wei-Shao WeiMartin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.ORCID 0000-0001-9467-4273
Anthony TrubianoMartin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.
Christian SiglLaboratory for Biomolecular Nanotechnology, Department of Physics, Technical University of Munich, Garching 85748, Germany.
Stefan PaquayMartin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.ORCID 0000-0003-4398-9587
Hendrik DietzLaboratory for Biomolecular Nanotechnology, Department of Physics, Technical University of Munich, Garching 85748, Germany.ORCID 0000-0003-1270-3662
Michael F HaganMartin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.ORCID 0000-0002-9211-2434
Seth FradenMartin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.ORCID 0000-0002-2420-9939
Brandeis University · USTechnical University of Munich · DE

Funding

Computational modeling of viral capsid and bacterial microcompartment assemblyR01GM108021 · NIGMS · BRANDEIS UNIVERSITY · PI HAGAN, MICHAEL F · 2013 to 2021
$2.7M
NIGMS NIH HHS R01 GM108021
6 · The paper itself

Abstract

Self-assembly of complex and functional materials remains a grand challenge in soft material science. Efficient assembly depends on a delicate balance between thermodynamic and kinetic effects, requiring fine-tuning affinities and concentrations of subunits. By contrast, we introduce an assembly paradigm that allows large error-tolerance in the subunit affinity and helps avoid kinetic traps. Our combined experimental and computational approach uses a model system of triangular subunits programmed to assemble into

Indexed as

CapsidMaterials ScienceCapsid ProteinsDNAKineticsThermodynamicsVirus AssemblyCapsid ProteinsDNAassembly pathwayDNA origamikineticspatchy colloidsself-assembly

Identifiers

PMID38324570
PMCPMC10873614
OpenAlexW4391594213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.