Evidence map›Paper›PMID 38324259›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2024

Effects of exogenous lactate on lipid, protein, and glucose metabolism-a randomized crossover trial in healthy males.

Mette G B Pedersen, Nikolaj Rittig, Maj Bangshaab, Kristoffer Berg-Hansen, Nigopan Gopalasingam, Lars C Gormsen, Esben Søndergaard, Niels Møller

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07426172 (Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07426172 narecruitingnot on this mapstarted 2026, after this paper: background citation

Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.

TypeinterventionalSponsorRicardo MoraRan2026 to 2028Enrolled24ConditionsHyperlactatemia, Metabolic Syndrome (MetS), Lipolysis, ExerciseArmshyperlactacidemia, Saline (0.9%, sterile, for infusion)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Cardiovascular effects of lactate in healthy adults.Critical care (London, England) · 2025
    Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mette G B PedersenSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3670-941X
Nikolaj RittigSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-9938-2181
Maj BangshaabSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Kristoffer Berg-HansenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Nigopan GopalasingamDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Lars C GormsenDepartment of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-0144-1305
Esben SøndergaardSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-8041-6994
Niels MøllerSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Steno Diabetes Centers · DKAarhus University Hospital · DK

Funding

Novo Nordisk Fonden (NNF) NNF19OC0055002
6 · The paper itself

Abstract

Lactate may inhibit lipolysis and thus enhance insulin sensitivity, but there is a lack of metabolic human studies. This study aimed to determine how hyperlactatemia affects lipolysis, glucose- and protein metabolism, and insulin sensitivity in healthy men. In a single-blind, randomized, crossover design, eight healthy men were studied after an overnight fast on two occasions:

Indexed as

HyperlactatemiaInsulin ResistanceBlood GlucoseCross-Over StudiesGlucoseGlucose Clamp TechniqueHumansInsulinLactic AcidMalePalmitatesPhenylalanineProteinsSingle-Blind MethodSodiumTyrosineBlood GlucoseGlucoseInsulinLactic AcidPalmitatesPhenylalanineProteinsSodiumTyrosineenergy expenditureinsulin sensitivitylactatelipolysisprotein metabolism

Identifiers

PMID38324259
PMCPMC11193511
OpenAlexW4391597961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.