ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.Heart (British Cardiac Society) · 2025Trial
- Imaging and biomarker-based risk stratification in TAVI: the role of epicardial fat, visceral fat, and adiponectin.European heart journal open · 2026Article
- Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis.ESC heart failure · 2025Article
- Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice.Basic research in cardiology · 2025Article
- Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation.International journal of cardiology. Heart & vasculature · 2025Article
- Body composition of metabolically unhealthy normal-weight patients with aortic stenosis: a prospective cohort study.BMC cardiovascular disorders · 2024Article
- Deep learning for opportunistic, end-to-end automated assessment of epicardial adipose tissue in pre-interventional, ECG-gated spiral computed tomography.Insights into imaging · 2024Article
- Clinical Advances in Cardiovascular Computed Tomography: From Present Applications to Promising Developments.Current cardiology reports · 2024Review
- Epicardial adipose tissue and muscle distribution affect outcomes in very old patients after transcatheter aortic valve replacement.European heart journal open · 2024Article
- Impact of epicardial adipose tissue on cardiac function and morphology in patients with diastolic dysfunction.ESC heart failure · 2024Article
- Novel CT-derived markers for enhanced long-term risk stratification in the planning of TAVR for aortic stenosis.Journal of cardiovascular computed tomographyReview
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Authors and funding
11 authors.
Funding
Abstract
backgroundAccurate risk stratification is important to improve patient selection and outcome of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). As epicardial adipose tissue (EAT) is discussed to be involved in cardiovascular disease, it could be useful as a marker of poor prognosis in patients with severe AS undergoing TAVR.
methodsA total of 416 patients diagnosed with severe AS by transthoracic echocardiography were assigned for TAVR and enrolled for systematic assessment. Patients underwent clinical surveys and 5-year long-term follow-up, with all-cause mortality as the primary endpoint. EAT volume was quantified on pre-TAVR planning CTs. Patients were retrospectively dichotomized at the median of 74 cm
resultsA total number of 341 of 416 patients (median age 80.9 years, 45% female) were included in the final analysis. Patients with high EAT volumes had similar short-term outcome (p = 0.794) but significantly worse long-term prognosis (p = 0.023) compared to patients with low EAT volumes. Increased EAT volumes were associated with worse long-term outcome (HR1.59; p = 0.031) independently from concomitant cardiovascular risk factors, general type of AS, and functional echocardiography parameters of AS severity (HR1.69; p = 0.013).
conclusionIncreased EAT volume is an independent predictor of all-cause mortality in patients with severe AS undergoing TAVR. It can be easily obtained from pre-TAVR planning CTs and may thus qualify as a novel marker to improve prognostication and management of patient with severe AS.
trial registrationDRKS, DRKS00024479.
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