Evidence map›Paper›PMID 38323756›Full record

ArticleEuropean journal of neurology2024

The epidemiology and societal costs of myasthenia gravis in Norway: A non-interventional study using national registry data.

Ingrid Engebretsen, Nils Erik Gilhus, Ivar Sønbø Kristiansen, Erik Magnus Sæther, Ingrid Lindberg-Schager, Fredrik Arneberg, Christoffer Bugge

Abstract read
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Disease changes and cost analysis of myasthenia gravis: a 10 years retrospective study from a reference center in Italy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  9. Low-dose IL-2 Ameliorates Experimental Autoimmune Myasthenia Gravis in Rats by Restoring the CD4-positive Helper T-cell Balance Via the JAK/STAT5 Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ingrid EngebretsenOslo Economics, Oslo, Norway.ORCID 0000-0001-9608-6731
Nils Erik GilhusDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Ivar Sønbø KristiansenOslo Economics, Oslo, Norway.
Erik Magnus SætherOslo Economics, Oslo, Norway.
Ingrid Lindberg-SchagerUCB Pharma AB, Stockholm, Sweden.ORCID 0000-0002-6549-6065
Fredrik ArnebergUCB Pharma AS, Oslo, Norway.
Christoffer BuggeOslo Economics, Oslo, Norway.ORCID 0000-0002-0766-2870

Funding

UCB Pharma
6 · The paper itself

Abstract

background and purposeWith the emergence of new treatment options for myasthenia gravis (MG), there is a need for information regarding epidemiology, healthcare utilization, and societal costs to support economic evaluation and identify eligible patients. We aimed to enhance the understanding of these factors using nationwide systematic registry data in Norway.

methodsWe received comprehensive national registry data from five Norwegian health- and work-related registries. The annual incidence and prevalence were estimated for the period 2013-2021 using nationwide hospital and prescription data. The direct, indirect (productivity losses) and intangible costs (value of lost life-years [LLY] and health-related quality of life [HRQoL]) related to MG were estimated over a period of 1 year.

resultsIn 2021, the incidence of MG ranged from 15 to 16 cases per year per million population depending on the registry used, while the prevalence varied between 208.9 and 210.3 per million population. The total annual societal costs of MG amounted to EUR 24,743 per patient, of which EUR 3592 (14.5%) were direct costs, EUR 8666 (35.0%) were productivity loss, and EUR 12,485 (50.5%) were lost value from LLY and reduced HRQoL.

conclusionThe incidence and prevalence of MG are higher than previously estimated, and the total societal costs of MG are substantial. Our findings demonstrate that productivity losses, and the value of LLY and HRQoL constitute a considerable proportion of the total societal costs.

Indexed as

Health Care CostsMyasthenia GravisCost of IllnessHumansNorwayQuality of LifeRoutinely Collected Health Datacost of illnessepidemiologyhealthcare costsmyasthenia gravisproductivity loss

Identifiers

PMID38323756
PMCPMC11235824

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.