Evidence map›Paper›PMID 38323585›Full record

ArticleTissue engineering. Part A2024

Effect of Passaging on Bovine Chondrocyte Gene Expression and Engineered Cartilage Production.

Emily D Lindberg, Serra Kaya, Amir A Jamali, Tamara Alliston, Grace D O'Connell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emily D LindbergDepartment of Mechanical Engineering, University of California-Berkeley, Berkeley, California, USA.
Serra KayaDepartment of Orthopedic Surgery, University of California-San Francisco, San Francisco, California, USA.
Amir A JamaliJoint Preservation Institute, Walnut Creek, California, USA.
Tamara AllistonDepartment of Orthopedic Surgery, University of California-San Francisco, San Francisco, California, USA.
Grace D O'ConnellDepartment of Mechanical Engineering, University of California-Berkeley, Berkeley, California, USA.
University of California, Berkeley · USUniversity of California, San Francisco · US

Funding

High-throughput screening of cell mechanics to direct 3D tissue cultureR21AR072248 · NIAMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI O'CONNELL, GRACE D · 2018 to 2019
$380k
NIAMS NIH HHS R21 AR072248
6 · The paper itself

Abstract

Tissue engineering strategies show great potential for repairing osteochondral defects in osteoarthritic joints; however, these approaches often rely on passaging cells multiple times to obtain enough cells to produce functional tissue. Unfortunately, monolayer expansion culture causes chondrocyte dedifferentiation, which is accompanied by a phenotypical and morphological shift in chondrocyte properties that leads to a reduction in the quality of

Indexed as

ChondrocytesTissue EngineeringAnimalsCartilageCattleCells, CulturedChondrogenesisExtracellular MatrixGene Expression RegulationHumanscartilage regenerationexpansion culturegrowth factor primingtissue engineering

Identifiers

PMID38323585
PMCPMC12918923
OpenAlexW4391614372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.