Article in Circulation. Genomic and precision medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors at 10 institutions in 4 countries.
Ravi V Shah *Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN (R.V.S., K.T., A.S.P., J.E.F.).
Jiawei ZhongDepartment of Medicine (H7), Karolinska Institutet, Stockholm, Sweden (J.Z., L.M., M.R.).ORCID 0000-0002-2802-0770
Lucas MassierDepartment of Medicine (H7), Karolinska Institutet, Stockholm, Sweden (J.Z., L.M., M.R.).ORCID 0000-0002-6199-2643
Kahraman TanriverdiVanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN (R.V.S., K.T., A.S.P., J.E.F.).ORCID 0000-0002-1491-8803
Shih-Jen HwangPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.-J.H., D.L.).ORCID 0000-0002-2129-5704
Jeffrey HaesslerFred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.).
Matthew NayorSections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Department of Medicine, and Department of Epidemiology, Boston University Schools of Medicine and Public Health, MA (M.N.).ORCID 0000-0002-6993-9396
Shilin ZhaoDepartment of Biostatistics, Vanderbilt University, Nashville, TN (S.Z.).ORCID 0000-0002-3921-3965
Andrew S PerryVanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN (R.V.S., K.T., A.S.P., J.E.F.).ORCID 0000-0003-3342-6158
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla (A.H.S.).
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.E.M.).ORCID 0000-0002-9426-7595
Lisa MartinGeorge Washington University School of Medicine and Health Sciences (L.M.).ORCID 0000-0003-4352-0914
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.-J.H., D.L.).ORCID 0000-0003-1843-8724
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.).ORCID 0000-0002-7986-8560
Jane E FreedmanVanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN (R.V.S., K.T., A.S.P., J.E.F.).ORCID 0000-0002-0011-6164
Mikael Rydén *Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden (J.Z., L.M., M.R.).ORCID 0000-0003-4785-1876
Venkatesh L Murthy *Department of Medicine and Radiology, University of Michigan, Ann Arbor (V.L.M.).ORCID 0000-0002-7901-1321
Vanderbilt University · USKarolinska Institutet · SECape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZANational Heart Lung and Blood Institute · USBrigham and Women's Hospital · USGeorge Washington University · USHuman Longevity (United States) · USNorthwestern University · USTwitter (United States) · USUniversity of Michigan · US
Funding
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Plasma Proteomic Signatures for Alzheimer's Disease and Related DementiasRF1AG079149 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN, SHADYAB, ALADDIN · 2022 to 2022
$7.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
Molecular markers of early cardiometabolic health transitions in the CARDIA studyR01HL136685 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURTHY, VENKATESH LOCHARLA, SHAH, RAVI · 2017 to 2021
$2.6M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
backgroundThe circulating proteome may encode early pathways of diabetes susceptibility in young adults for surveillance and intervention. Here, we define proteomic correlates of tissue phenotypes and diabetes in young adults.
methodsWe used penalized models and principal components analysis to generate parsimonious proteomic signatures of diabetes susceptibility based on phenotypes and on diabetes diagnosis across 184 proteins in >2000 young adults in the CARDIA (Coronary Artery Risk Development in Young Adults study; mean age, 32 years; 44% women; 43% Black; mean body mass index, 25.6±4.9 kg/m
resultsIn 184 proteins in >2000 young adults in CARDIA, we identified 2 proteotypes of diabetes susceptibility-a proinflammatory fat proteotype (visceral fat, liver fat, inflammatory biomarkers) and a muscularity proteotype (muscle mass), linked to diabetes in CARDIA and WHI/FHS. These proteotypes specified broad mechanisms of early diabetes pathogenesis, including transorgan communication, hepatic and skeletal muscle stress responses, vascular inflammation and hemostasis, fibrosis, and renal injury. Using human adipose tissue single cell/nuclear RNA-seq, we demonstrate expression at transcriptional level for implicated proteins across adipocytes and nonadipocyte cell types (eg, fibroadipogenic precursors, immune and vascular cells). Using functional assays in human adipose tissue, we demonstrate the association of expression of genes encoding these implicated proteins with adipose tissue metabolism, inflammation, and insulin resistance.
conclusionsA multifaceted discovery effort uniting proteomics, underlying clinical susceptibility phenotypes, and tissue expression patterns may uncover potentially novel functional biomarkers of early diabetes susceptibility in young adults for future mechanistic evaluation.
Indexed as
Diabetes Mellitus, Type 2ProteomicsAdipose TissueAdultBiomarkersFemaleHumansInflammationMaleYoung AdultBiomarkersinsulin resistancemetabolismproteomicstranscriptomics
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults. · full record | OpenQuestion