Evidence map›Paper›PMID 38323450›Full record

ArticleStroke2024

Electronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats.

Hari Pradhyumnan, Shahil H Patel, Ofelia Furones-Alonso, Weizhao Zhao, Helen M Bramlett, Ami P Raval

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Hari Pradhyumnan *Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (H.P., S.H.P., A.P.R.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0002-9464-0345
Shahil H Patel *Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (H.P., S.H.P., A.P.R.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0009-0001-3423-7503
Ofelia Furones-AlonsoDepartment of Neurological Surgery (O.F.-A., H.M.B.), University of Miami Leonard M. Miller School of Medicine, FL.
Weizhao ZhaoDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL (W.Z.).ORCID 0000-0002-9890-5785
Helen M BramlettDepartment of Neurological Surgery (O.F.-A., H.M.B.), University of Miami Leonard M. Miller School of Medicine, FL.
Ami P RavalPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (H.P., S.H.P., A.P.R.), University of Miami Leonard M. Miller School of Medicine, FL.
University of Miami · USBrain Physiology Lab · FRMACOM (United States) · USTwitter (United States) · US

Funding

Therapeutic interventions for post-stroke rehabilitationI01RX003506 · VA · MIAMI VA HEALTH CARE SYSTEM · PI BRAMLETT, HELEN M, RAVAL, AMI P · 2022 to 2025
–
RRD VA I01 RX003506
6 · The paper itself

Abstract

backgroundNicotine-containing electronic cigarette (EC) vaping has become popular worldwide, and our understanding of the effects of vaping on stroke outcomes is elusive. Using a rat model of transient middle cerebral artery occlusion, the current exploratory study aims to evaluate the sex-dependent effects of EC exposure on brain energy metabolism and stroke outcomes.

methodsAdult Sprague-Dawley rats of both sexes were randomly assigned to air/EC vapor (5% nicotine Juul pods) exposure for 16 nights, followed by randomization into 3 cohorts. The first cohort underwent exposure to air/EC preceding randomization to transient middle cerebral artery occlusion (90 minutes) or sham surgery, followed by survival for 21 days. During the survival period, rats underwent sensorimotor and Morris water maze testing. Subsequently, brains were collected for histopathology. A second cohort was exposed to air/EC after which brains were collected for unbiased metabolomics analysis. The third cohort of animals was exposed to air/EC and received transient middle cerebral artery occlusion/sham surgery, and brain tissue was collected 24 hours later for biochemical analysis.

resultsIn females, EC significantly increased (

conclusionsEven brief EC exposure over 2 weeks impacts brain energy metabolism, exacerbates infarction, and worsens poststroke cognitive deficits in working memory more in female than male rats.

Indexed as

Electronic Nicotine Delivery SystemsVapingAdultAnimalsFemaleHumansInfarction, Middle Cerebral ArteryMaleNicotineRatsRats, Sprague-DawleyNicotineelectronic nicotine delivery systemsglycolysisicotineMorris water maze testvaping

Identifiers

PMID38323450
PMCPMC10940219
OpenAlexW4391605050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.