Evidence map›Paper›PMID 38323297›Full record

ReviewJournal of biomedical optics2024

Sounding out the dynamics: a concise review of high-speed photoacoustic microscopy.

Soon-Woo Cho, Van Tu Nguyen, Anthony DiSpirito, Joseph Yang, Chang-Seok Kim, Junjie Yao

Abstract readReview
In one paragraph

Review in Journal of biomedical optics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Soon-Woo ChoDuke University, Department of Biomedical Engineering, Durham, North Carolina, United States.ORCID 0000-0002-5019-1429
Van Tu NguyenDuke University, Department of Biomedical Engineering, Durham, North Carolina, United States.ORCID 0000-0002-4913-438X
Anthony DiSpiritoDuke University, Department of Biomedical Engineering, Durham, North Carolina, United States.ORCID 0000-0002-3232-7353
Joseph YangDuke University, Department of Biomedical Engineering, Durham, North Carolina, United States.ORCID 0009-0007-4622-5757
Chang-Seok KimPusan National University, Engineering Research Center for Color-Modulated Extra-Sensory Perception Technology, Busan, Republic of Korea.ORCID 0000-0002-2811-8137
Junjie YaoDuke University, Department of Biomedical Engineering, Durham, North Carolina, United States.ORCID 0000-0002-2381-706X

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Next-Generation Ultrasound Localization MicroscopyR21EB030072 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SONG, PENGFEI · 2020 to 2022
$927k
Transcranial Photoacoustic Imaging Using a Virtual ArrayR21EB027981 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI JING, YUN · 2020 to 2020
$455k
Photoacoustic-imaging-guided intravascular sonothrombolysisR21EB027304 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING, YAO, JUNJIE · 2019 to 2020
$411k
NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB027304NIBIB NIH HHS R21 EB027981NIBIB NIH HHS R21 EB030072NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

Significance: Photoacoustic microscopy (PAM) offers advantages in high-resolution and high-contrast imaging of biomedical chromophores. The speed of imaging is critical for leveraging these benefits in both preclinical and clinical settings. Ongoing technological innovations have substantially boosted PAM's imaging speed, enabling real-time monitoring of dynamic biological processes. Aim: This concise review synthesizes historical context and current advancements in high-speed PAM, with an emphasis on developments enabled by ultrafast lasers, scanning mechanisms, and advanced imaging processing methods. Approach: We examine cutting-edge innovations across multiple facets of PAM, including light sources, scanning and detection systems, and computational techniques and explore their representative applications in biomedical research. Results: This work delineates the challenges that persist in achieving optimal high-speed PAM performance and forecasts its prospective impact on biomedical imaging. Conclusions: Recognizing the current limitations, breaking through the drawbacks, and adopting the optimal combination of each technology will lead to the realization of ultimate high-speed PAM for both fundamental research and clinical translation.

Indexed as

MicroscopyPhotoacoustic TechniquesLasersProspective StudiesSpectrum Analysiscomputational techniquesdeep-learninghigh-speed light sourcehigh-speed scanningoptical acoustic detectionoptoacoustic microscopyphotoacoustic microscopy

Identifiers

PMID38323297
PMCPMC10846286

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.