Evidence map›Paper›PMID 38323255›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2024

Fecal Microbiota Transplantation for

Parikshit Shirish Prayag, Sampada Ajeet Patwardhan, Preeti Shankarrao Ajapuje, Sameer Melinkeri, Harshal Gadhikar, Sachin Palnitkar, Ramya Simbasivam, Rasika Saheel Joshi, Abhijit Baheti, Urmi Sitanshu Sheth and 1 more

Abstract read
In one paragraph

Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lurking Danger: Emerging Evidence.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parikshit Shirish PrayagDepartment of Infectious Diseases, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0003-2102-7627
Sampada Ajeet PatwardhanDepartment of Microbiology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0003-0998-5742
Preeti Shankarrao AjapujeDepartment of Infectious Diseases, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0003-4095-3028
Sameer MelinkeriDepartment of Clinical Hematology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0003-4608-4281
Harshal GadhikarDepartment of Gastroenterology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0009-0000-5422-7452
Sachin PalnitkarDepartment of Gastroenterology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0002-5619-0662
Ramya SimbasivamDepartment of Infectious Diseases, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0003-0673-5684
Rasika Saheel JoshiDepartment of Infectious Diseases, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0009-0005-1551-0390
Abhijit BahetiDepartment of Clinical Hematology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0009-0007-4900-0887
Urmi Sitanshu ShethDepartment of Clinical Hematology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0009-0006-7041-1149
Amrita Parikshit PrayagDepartment of In-house Research, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.ORCID https://orcid.org/0000-0002-2498-9576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Fecal microbiota transplantation (FMT) is an emerging option for recurrent or refractory Methods: A prospective observational study of HSCT recipients with CDAD who received FMT in our center. Results: A total of 13 patients were included. All the patients were allogenic HSCT recipients; FMT was performed in seven patients due to refractory CDAD, in five patients due to the presence of both CDAD and graft vs host disease (GVHD), and in 1 patient due to recurrent CDAD. The approach to FMT was colonoscopic in 10 (77%) patients. Only one patient reported bacteremia and one patient had candidemia, both of which were unrelated to FMT. Of the 10 patients who had complete resolution of CDAD, only one patient presented with a recurrence of CDAD within 8 weeks post-FMT. Conclusion: This is the first study from India using FMT as a therapeutic modality for CDAD in the setting of HSCT. Here we demonstrate that FMT in India is an effective option, especially when patients have refractory CDAD, recurrent CDAD, or both GVHD and CDAD. Further studies should explore the efficacy and feasibility of FMT in India. How to cite this article: Prayag PS, Patwardhan SA, Ajapuje PS, Melinkeri S, Gadhikar H, Palnitkar S,

Indexed as

Clostridium difficileClostridium difficile-associated diarrheaFecal microbiota transplantationHematopoietic stem cell transplantation

Identifiers

PMID38323255
PMCPMC10839937

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.