Evidence map›Paper›PMID 38323001›Full record

ArticleiScience2024

Alleviation of monocyte exhaustion by BCG derivative mycolic acid.

Yajun Wu, Blake Caldwell, Jing Wang, Yao Zhang, Liwu Li

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  5. Article
  6. Propagation of monocyte exhaustion memory and underlying mechanisms.Cell communication and signaling : CCS · 2025
    Article
  7. Article
  8. Review
  9. The role of trained immunity in sepsis.Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yajun WuDepartment of Biological Sciences, Virginia Tech; Blacksburg, VA 24061-0910, USA.
Blake CaldwellDepartment of Biological Sciences, Virginia Tech; Blacksburg, VA 24061-0910, USA.
Jing WangDepartment of Biological Sciences, Virginia Tech; Blacksburg, VA 24061-0910, USA.
Yao ZhangDepartment of Biological Sciences, Virginia Tech; Blacksburg, VA 24061-0910, USA.
Liwu LiDepartment of Biological Sciences, Virginia Tech; Blacksburg, VA 24061-0910, USA.
Virginia Tech · US

Funding

Modulation of innate immune exhaustion during sepsisR01AI172133 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LIWU LI · 2023 to 2026
$2.2M
IGNITE KUH NRSA Training CoreTL1DK132771 · NIDDK · UNIVERSITY OF VIRGINIA · PI PORTILLA, DIDIER · 2021 to 2025
$1.9M
Integrated Virginia Research Training Centers in KUH (IGNITE KUH)U2CDK129500 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHARMA, RAHUL · 2021 to 2025
$1.4M
NIAID NIH HHS R01 AI172133NIDDK NIH HHS TL1 DK132771NIDDK NIH HHS U2C DK129500
6 · The paper itself

Abstract

Monocyte exhaustion with sustained pathogenic inflammation and immune-suppression, a hallmark of sepsis resulting from systemic infections, presents a challenge with limited therapeutic solutions. This study identified Methoxy-Mycolic Acid (M-MA), a branched mycolic acid derived from

Indexed as

EpigeneticsImmunologyMolecular biology

Identifiers

PMID38323001
PMCPMC10845070
OpenAlexW4391065320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.