Evidence map›Paper›PMID 38322935›Full record

ArticleHeliyon2024

One month follow-up of carotid endarterectomy with in-hospital preoperative aspirin monotherapy and postoperative dual antiplatelet therapy in asymptomatic and symptomatic patients: A multi-center study.

Tonglei Han, Hanfei Tang, Changpo Lin, Jiaqi Zhu, Yang Shen, Dong Yan, Zhiqing Zhao, Jiang Lin, Bin Gao, Yi Si and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Tonglei HanDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Hanfei TangDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Changpo LinDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Jiaqi ZhuDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Yang ShenDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Dong YanDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Zhiqing ZhaoDepartment of Vascular Surgery, Changhai Hospital, The PLA Naval Medical University, Shanghai, 200433, China.
Jiang LinDepartment of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical Imaging, Shanghai, 200030, China.
Bin GaoDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Yi SiDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Xiaolong WeiDepartment of Vascular Surgery, Changhai Hospital, The PLA Naval Medical University, Shanghai, 200433, China.
Xiao TangDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Daqiao GuoDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.
Weiguo FuDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is currently no consensus regarding the optimal perioperative antiplatelet strategy for carotid artery surgery. This multicentre study aimed to analyse the association between preoperative aspirin monotherapy following postoperative dual antiplatelet therapy (DAPT) and the risk for stroke and death after carotid endarterectomy (CEA). Methods: This cohort study included 821 patients with carotid artery stenosis who underwent CEA. Primary outcomes included any stroke or death up to the one-month postoperative follow-up. Multilevel multivariate regression analyses and descriptive statistics were performed. Results: Patients were predominantly male (53 %), with a mean age of 66.2 years. The primary outcome occurred in 1.6 % of patients. Univariate and multivariate analyses revealed that patients with chronic obstructive pulmonary disease (COPD) exhibited a high risk for stroke or death (P = 0.011). The occurrence of any local complications in the neck was accompanied by an increase in diastolic blood pressure (DBP) (P = 0.007). Patients with a high systolic blood pressure (SBP) (P = 0.002) experienced a longer operative duration. The length of hospital stay was longer in the patients with COPD (P = 0.020), minor stroke (P = 0.011), and major stroke (P = 0.001). A positive linear correlation was found between SBP and operative duration in the overall population (β 0.4 [95 % confidence interval (CI) 0.1-0.7]; P = 0.002). The resultant curve for DBP and any local complications in the neck exhibited a two-stage change and one breakpoint in the entire population (k = 68 mmHg, <68; odds ratio [OR] 0.9 [95 % CI 0.7-1.1], P = 0.461; ≥68: OR 1.1 [95 % CI 1.0-1.1], P = 0.003). Conclusions: Preoperative aspirin monotherapy and postoperative DAPT were safe and effective antiplatelet treatments for patients who underwent CEA.

Indexed as

Antiplatelet therapyCarotid artery stenosisCarotid endarterectomyPeri-operative complicationsStroke

Identifiers

PMID38322935
PMCPMC10844113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.