Evidence map›Paper›PMID 38322892›Full record

ArticleHeliyon2024

Comparable analysis of six immunoassays for carcinoembryonic antigen detection.

Wenxuan Fu, Yuhong Yue, Yichuan Song, Shunli Zhang, Jie Shi, Rui Zhao, Qingtao Wang, Rui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenxuan FuDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Yuhong YueDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Yichuan SongDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Shunli ZhangDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Jie ShiDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Rui ZhaoDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Qingtao WangDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Rui ZhangDepartment of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to assess the current status of carcinoembryonic antigen (CEA) detection. We evaluated the correlation, consistency, and comparability of CEA results among six automated immunoassays, and combined with the results of CEA trueness verification of the Beijing Center for Clinical Laboratories (BCCL) for further analysis. Methods: Abbott Architect i2000, Beckman DxI800, Roche Cobas E601, Diasorin Liaison XL, Maccura IS1200, and Autolumo A2000 were used to detect 40 individual serum CEA samples. Taking the optimal analytical quality specifications calculated from data on biological variation as the evaluation criterion. Passing-Bablok regression and Bland-Altman analysis were performed between each assay and all-assays median values to evaluate the correlation and relative difference. The concordance correlation coefficient (CCC) was used for consistency analysis. Additionally, the trueness verification program used samples at three concentration levels to assess the bias, coefficient of variation (CV), and total error (TE) between the average measured values and the target value. Results: The Spearman's rank correlation coefficient (r Conclusions: The six automated immunoassays vs. all-assays median have a good correlation in CEA detection. However, there is a lack of comparability of CEA results. Further improvements are needed in harmonization among CEA detections.

Indexed as

Assay comparisonCarcinoembryonic antigenImmunoassayTrueness verification program

Identifiers

PMID38322892
PMCPMC10845681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.