Evidence map›Paper›PMID 38322777›Full record

ReviewAJOG global reports2024

The role of probiotics and synbiotics on treatment of gestational diabetes: systematic review and meta-analysis.

Arresta Vitasatria Suastika, I Gde Raka Widiana, Ni Nengah Dwi Fatmawati, Ketut Suastika, Ivana Beatrice Paulus, I Nengah Sujaya

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in AJOG global reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Nutrients · 2025
    Trial
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arresta Vitasatria SuastikaUdayana Medical School, Denpasar, Bali, Indonesia (Dr A Suastika).
I Gde Raka WidianaDepartment of Internal Medicine, Udayana University, Bali, Indonesia (Drs I Widiana and K Suastika).
Ni Nengah Dwi FatmawatiFaculty of Medicine, Department of Microbiology, Udayana University, Bali, Indonesia (Dr N Fatmawati).
Ketut SuastikaDepartment of Internal Medicine, Udayana University, Bali, Indonesia (Drs I Widiana and K Suastika).
Ivana Beatrice PaulusWangaya General Hospital, Denpasar, Bali, Indonesia (Dr Paulus).
I Nengah SujayaFaculty of Medicine, School of Public Health, Udayana University, Bali, Indonesia (N Sujaya PhD).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis review investigated the efficacy of probiotics and/or synbiotics in gestational diabetes mellitus treatment by targeting insulin resistance, lipid metabolism, and anti-inflammatory effects in an updated trial. DATA SOURCES: The literature review was performed using the key words "Probiotics," "Synbiotics," and "Gestational Diabetes" in several databases, including PubMed, ScienceDirect, and the Cochrane Central Register of Controlled Trials. STUDY ELIGIBILITY CRITERIA: Eligible publication was screened independently by 2 reviewers. Studies included provided at least 1 of the following outcomes: (1) blood glucose marker, including fasting blood glucose level, fasting serum insulin level, and homeostasis model assessment insulin resistance; (2) blood lipid profiles, including triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol; and (3) nitric oxide and C-reactive protein.

methodsAll studies were reviewed using the critical appraisal Cochrane risk-of-bias tool for randomized trials. The descriptions of the extracted data were guided by the Preferred Reporting Items for Systematic Reviews 2020 statement with the Grading of Recommendations Assessment, Development, and Evaluation approach. This study was registered on the International Prospective Register of Systematic Reviews database (identification number: CRD42022375665).

resultsFrom 13 randomized controlled trials involving 896 patients, individuals with probiotic had significant reduction on homeostasis model assessment insulin resistance (mean difference, -0.72; 95% confidence interval, -1.07 to -0.38;

conclusionProbiotic and synbiotic supplementations reduced the risk of insulin resistance and improved glycemic control, blood lipid profiles, and inflammation in women with gestational diabetes mellitus. Probiotics may be a viable option for gestational diabetes mellitus treatment; however, large-scale, well-designed randomized controlled trials with longer follow-up periods are required before they can be recommended to patients.

Indexed as

gestational diabetes mellitusprobioticsynbiotics

Identifiers

PMID38322777
PMCPMC10844859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.