Evidence map›Paper›PMID 38322337›Full record

ArticleActa pharmaceutica Sinica. B2024

Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng.

Shining Loo, Antony Kam, Bamaprasad Dutta, Xiaohong Zhang, Nan Feng, Siu Kwan Sze, Chuan-Fa Liu, Xiaoliang Wang, James P Tam

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shining LooSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Antony KamSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Bamaprasad DuttaSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Xiaohong ZhangSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Nan FengInstitute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
Siu Kwan SzeSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Chuan-Fa LiuSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Xiaoliang WangSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
James P TamSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress and illness connection is complex and involves multiple physiological systems. Panax ginsengs, reputed for their broad-spectrum "cure-all" effect, are widely prescribed to treat stress and related illnesses. However, the identity of ginseng's "cure-all" medicinal compounds that relieve stress remains unresolved. Here, we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to stress. Ginsentides are disulfide-rich, cell-penetrating and proteolytic-stable microproteins. Using affinity-enrichment mass spectrometry target identification together with

Indexed as

Cure-allCysteine-rich peptidesGinsengHomeostasisMicroproteinsStress

Identifiers

PMID38322337
PMCPMC10840477

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.