Evidence map›Paper›PMID 38322242›Full record

ArticleFrontiers in pediatrics2023

pCO2 values in asphyxiated infants under therapeutic hypothermia after tailored respiratory management: a retrospective cohort study.

Francesca Serrao, Eloisa Tiberi, Tommaso Verdolotti, Domenico Marco Maurizio Romeo, Mirta Corsello, Elisa Pede, Francesco Cota, Simonetta Costa, Francesca Gallini, Cesare Colosimo and 2 more

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Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca SerraoDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Eloisa TiberiDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Tommaso VerdolottiRadiology and Neuroradiology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Domenico Marco Maurizio RomeoPediatric Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Mirta CorselloDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Elisa PedePediatric Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Francesco CotaDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Simonetta CostaDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Francesca GalliniDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Cesare ColosimoRadiology and Neuroradiology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Eugenio Maria MercuriPediatric Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Giovanni VentoDivision of Neonatology, Department of Women, Children and Public Health Sciences, University Hospital Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypoxic-ischemic encephalopathy (HIE) represents one of the major causes of neonatal death and long-term neurological disability. Both hypoxic-ischemic insults and therapeutic hypothermia (TH) can affect respiratory function. Currently, there is no evidence regarding optimal respiratory management in these infants. Methods: This is a retrospective cohort study examining newborns with HIE treated with TH between January 2015 and September 2020. The study population was divided into two groups based on different respiratory assistance during TH: spontaneous breathing (Group A) or mechanical ventilation (Group B). The primary outcome of the study was the mean pCO Results: A total of 126 newborns were enrolled, 75 in Group A and 51 in Group B. Respiratory management was individualized, and volume guarantee (VG) ventilation was the first choice for ventilated infants. Group B infants showed more severe conditions at birth. During TH, ventilated infants showed optimal mean pCO Conclusions: Infants cooled after HIE should receive individualized respiratory management, not necessarily involving intubation. In those infants requiring mechanical ventilation, a volume-targeted strategy appeared to be effective in maintaining stable blood gas levels. Short-term neurological outcomes appeared comparable in ventilated and non-ventilated infants.

Indexed as

hypocapniahypoxic ischemic encephalopathymechanical ventilationperinatal asphyxiatherapeutic hypothermia

Identifiers

PMID38322242
PMCPMC10844519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.