ArticleNorth American Spine Society journal2024
Predictive factors of symptomatic lumbar pseudoarthrosis following multilevel primary lumbar fusion.
Article in North American Spine Society journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Timing Matters: Preoperative Lumbar Epidural Steroid Injection and Long-Term Outcomes Following Single-Level Posterior Lumbar Fusion.Global spine journal · 2026Article
- Article
- Lateral lumbar interbody fusion to address pseudarthrosis after prior posterior spinal instrumentation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Influence of endplate degeneration on fusion process in lateral lumbar interbody fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Incidence and predictors of early and late reoperation after primary lumbar spine fusion: a 10-year retrospective cohort study of 1,356 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Posterior Lumbar Fusion Is Being Performed for Patients of Increasing Comorbidity Burden Over the Years, but Adverse Events Are Not Going Up.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Index Hospital Costs and Postoperative Outcomes of Lumbar Spine Fusion With FIBERGRAFT Vs Bone Morphogenic Protein-2: A Propensity Score-Matched Analysis.International journal of spine surgery · 2026Article
- The impact of bone graft volume on risk of pseudarthrosis, screw loosening, and rod breakage in surgical correction of adult spinal deformity.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Osteointegration and Fusion After TLIF: Trabecular Titanium Cage with SVF-Hydrogel Compared with PEEK Cage.Orthopedic reviews · 2026Article
- CT Evaluation of Lumbar Interbody Fusion: A Comprehensive Review with an Integrated Framework for Principle-Based Interpretation.Diagnostics (Basel, Switzerland) · 2026Review
- A Systematic Review of Metal Composite Bone Grafts in Preclinical Spinal Fusion Models.Biomimetics (Basel, Switzerland) · 2025Review
- Review
- Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection.Brain sciences · 2025Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lumbar spinal fusion surgery is a well-established treatment for various spinal disorders. However, one of its complications, pseudoarthrosis, poses a significant concern. This study aims to explore the incidence, time and predictive factors contributing to pseudoarthrosis in patients who have undergone lumbar fusion surgery over a 10-year period. Methods: Data for this research was sourced from the PearlDiver database where insurance claims of patients who underwent multilevel lumbar spinal fusion between 01/01/2010 and 10/31/2022 were examined for claims of pseudoarthrosis within the 10 years of their index procedure. A variety of demographic, comorbid, and surgical factors were assessed, including age, gender, Elixhauser Comorbidity Index (ECI), surgical approach, substance use disorders and history of spinal disorders. Statistical analyses, including chi-squared tests, multivariate analysis, and cox survival analysis were employed to determine significant associations. Results: Among the 76,337 patients included in this retrospective study, 2.70% were diagnosed with symptomatic lumbar pseudoarthrosis at an average of 7.38 years in a 10-year follow-up. Multivariate and Cox hazard analyses revealed that significant predictors of symptomatic pseudoarthrosis development following multilevel primary lumbar fusion include vitamin D deficiency, osteoarthritis, opioid and NSAID use, tobacco use, and a prior history of congenital spine disorders. Conclusions: In summary, this study revealed a 2.70% incidence of symptomatic lumbar pseudoarthrosis within 10 years of the index procedure. It highlighted several potential predictive factors, including comorbidities, surgical approaches, and substance use disorders, associated with the development of symptomatic pseudoarthrosis. Future research should focus on refining our understanding of these factors to improve patient outcomes and optimize healthcare resource allocation.
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