Evidence map›Paper›PMID 38321936›Full record

ArticleJournal of attention disorders2024

Neural and Cognitive Predictors of Stimulant Treatment Efficacy in Medication-Naïve ADHD Adults: A Pilot Diffusion Tensor Imaging Study.

Yuwen Hung, Allison Green, Caroline Kelberman, Schuyler Gaillard, James Capella, Nicole Rudberg, John D E Gabrieli, Joseph Biederman, Mai Uchida

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of attention disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Clinical predictors of stimulant efficacy in adults with ADHD.Therapeutic advances in psychopharmacology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yuwen HungMassachusetts Institute of Technology, Cambridge, USA.
Allison GreenMassachusetts General Hospital, Boston, USA.
Caroline KelbermanMassachusetts General Hospital, Boston, USA.
Schuyler GaillardMassachusetts Institute of Technology, Cambridge, USA.
James CapellaMassachusetts Institute of Technology, Cambridge, USA.
Nicole RudbergWestern University, London, ON, Canada.
John D E GabrieliMassachusetts Institute of Technology, Cambridge, USA.
Joseph BiedermanMassachusetts General Hospital, Boston, USA.
Mai UchidaMassachusetts General Hospital, Boston, USA.ORCID 0000-0003-1465-2635
Massachusetts Institute of Technology · USHarvard University · USMassachusetts General Hospital · USWestern University · CA

Funding

Neural and Clinical Biomarkers of Risk for ADHD: A Focus on PreschoolersK23MH122667 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI UCHIDA, MAI · 2020 to 2024
$998k
NIMH NIH HHS K23 MH122667
6 · The paper itself

Abstract

objectiveStimulant medications are the main treatment for Attention Deficit Hyperactivity Disorder (ADHD), but overall treatment efficacy in adults has less than a 60% response rate. This study aimed to identify neural and cognitive markers predictive of longitudinal improvement in response to stimulant treatment in drug-naïve adults with ADHD.

methodWe used diffusion tensor imaging (DTI) and executive function measures with 36 drug-naïve adult ADHD patients in a prospective study design.

resultsStructural connectivity (measured by fractional anisotropy, FA) in striatal regions correlated with ADHD clinical symptom improvement following stimulant treatment (amphetamine or methylphenidate) in better medication responders. A significant positive correlation was also found between working memory performance and stimulant-related symptom improvement. Higher pre-treatment working memory scores correlated with greater response.

conclusionThese findings provide evidence of pre-treatment neural and behavioral markers predictive of longitudinal treatment response to stimulant medications in adults with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateAdultAmphetamineCognitionDiffusion Tensor ImagingHumansProspective StudiesTreatment OutcomeAmphetamineCentral Nervous System StimulantsMethylphenidateADHDdiffusion tensor imagingdrug responsestimulantsworking memory

Identifiers

PMID38321936
PMCPMC10964228
OpenAlexW4391607338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.