Evidence map›Paper›PMID 38321900›Full record

ArticleCurrent pharmaceutical biotechnology2024

Long Non-coding RNA DLEU1 Promotes Progression of Osteoarthritis via miR-492/

Chenzhe Ni, Wanglin Zhang, Sai Qiu, Hao Cheng, Chunhui Ma

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Article in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chenzhe NiDepartment of Orthopaedics, Qidong People's Hospital, Nantong University, Jiangsu, 226200, China.
Wanglin ZhangDepartment of Orthopaedics, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Sai QiuDepartment of Orthopaedics, Qidong People's Hospital, Nantong University, Jiangsu, 226200, China.
Hao ChengDepartment of Orthopaedics, Qidong People's Hospital, Nantong University, Jiangsu, 226200, China.
Chunhui MaDepartment of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.

Funding

Natural Science Foundation of Shanghai Project no. 22ZR1450300
6 · The paper itself

Abstract

backgroundLong non-coding RNAs (LncRNAs) are generally reported to participate in the development of Osteoarthritis (OA) by acting as competing endogenous RNAs (ceRNAs). However, the molecular mechanism is largely unknown. This study aimed to investigate the possible mechanisms contributing to osteoarthritis (OA).

methodsFour gene expression profiles from patients with OA were downloaded from a public database and integrated to screen important RNAs associated with OA. Differentially expressed (DE) lncRNAs, microRNAs (miRNAs), and mRNAs were filtered, and a ceRNA network was constructed. An in vitro OA model was established by treating chondrocytes with IL-1β. The expression levels of MMP-13, COL2A1, aggrecan, and RUNX2 were detected by qRT-PCR and western blot. Cell proliferation ability was detected by CCK-8 assay. Flow cytometry was used for apoptosis assay. A dual luciferase reporter gene was used to confirm the relationship between DLEU1, miR-492, and

resultsAn OA-related ceRNA network, including 11 pathways, 3 miRNAs, 7 lncRNAs, and 16 mRNAs, was constructed. DLEU1 and

conclusionDLEU1 may be responsible for the viability, apoptosis, and ECM degradation in OA via miR-492/

Indexed as

ChondrocytesMicroRNAsOsteoarthritisRNA, Long NoncodingToll-Like Receptor 8ApoptosisCell ProliferationCells, CulturedDisease ProgressionHumansInterleukin-1betaDLEU1 lncRNA, humanInterleukin-1betaMicroRNAsRNA, Long NoncodingToll-Like Receptor 8competing endogenous RNA.DLEU1miR-492OsteoarthritisTLR8weighed gene co-expression network analysis

Identifiers

PMID38321900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.