Evidence map›Paper›PMID 38321899›Full record

ArticleCurrent pharmaceutical biotechnology2025

Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles.

Thais Silva Correa, William Gustavo Lima, Aline Beatriz do Couto Campos, Alexsandro Sobreira Galdino, Emilia Celma de Oliveira Lima, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Mariana Campos-da-Paz

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Article in Current pharmaceutical biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Thais Silva CorreaDepartment of Biochemistry, Federal University of São João del Rei, Divinópolis, MG, 35500-291, Brazil.
William Gustavo LimaSchool of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Aline Beatriz do Couto CamposSchool of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Alexsandro Sobreira GaldinoDepartment of Biochemistry, Federal University of São João del Rei, Divinópolis, MG, 35500-291, Brazil.
Emilia Celma de Oliveira LimaInstitute of Chemistry, Federal University of Goiás, Goiânia, GO, Brazil.
Valbert Nascimento CardosoSchool of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Simone Odília Antunes FernandesSchool of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Mariana Campos-da-PazDepartment of Biochemistry, Federal University of São João del Rei, Divinópolis, MG, 35500-291, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais - FAPEMIG REMITRIBIC, RED-00031-21
6 · The paper itself

Abstract

introductionActive targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals.

methodsWe synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium-99m (

resultsThese data suggest that anti-CEA decoration might be responsible for a delay in renal clearance. Regarding the tumor,

conclusionThese data validated the ability of active tumor targeting by the as-developed anti- CEA loaded nanoparticles and are very promising results for the future development of a nanodevice for the management of breast cancer and other types of CEA-positive tumors.

Indexed as

Carcinoembryonic AntigenMice, Inbred BALB CTechnetiumAnimalsCell Line, TumorFemaleMiceTissue DistributionCarcinoembryonic AntigenTechnetiumbreast cancercarcinoembryonic antigenmagnetic nanoparticlesnanotechnologyTargetingtheranostic.

Identifiers

PMID38321899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.