Evidence map›Paper›PMID 38321530›Full record

ReviewRespiratory research2024

Circular RNAs and their roles in idiopathic pulmonary fibrosis.

Akshaya Surendran, Chaoqun Huang, Lin Liu

Open access · goldAbstract readReview
In one paragraph

Review in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Akshaya SurendranThe Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK, 74078, USA.
Chaoqun HuangThe Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK, 74078, USA.
Lin LiuThe Lundberg-Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK, 74078, USA. lin.liu@okstate.edu.
Oklahoma State University · US

Funding

ZFC3H1 Regulation of Host Defense and Influenza A Virus PathogenesisP20GM103648 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI PATRAUCHAN, MARIANNA M. A. · 2013 to 2022
$22.3M
Pilot Project Grant ProgramP30GM149368 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LIN LIU · 2023 to 2026
$5.5M
The Role of Iron In Pulmonary FibrosisR01HL157450 · NHLBI · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LIN LIU · 2023 to 2026
$2.0M
The Role of LncRNAs in Pulmonary FibrosisR01HL135152 · NHLBI · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LIU, LIN · 2017 to 2020
$1.5M
Lnc-PINK regulation of innate immunity in lung epithelial cellsR21AI152004 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LIU, LIN · 2021 to 2022
$411k
NHLBI NIH HHS R01 HL135152NHLBI NIH HHS R01 HL157450NIAID NIH HHS R21 AI152004NIGMS NIH HHS P20 GM103648NIGMS NIH HHS P30 GM149368NIH HHS R01HL135152, R01HL157450, R21AI152004, P20GM103648 and P30GM149368
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Circular RNAs (circRNAs) have emerged as a novel class of non-coding RNAs with diverse functions in cellular processes. This review paper aims to explore the potential involvement of circRNAs in the pathogenesis of IPF and their diagnostic and therapeutic implications. We begin by providing an overview of the epidemiology and risk factors associated with IPF, followed by a discussion of the pathophysiology underlying this complex disease. Subsequently, we delve into the history, types, biogenesis, and functions of circRNAs and then emphasize their regulatory roles in the pathogenesis of IPF. Furthermore, we examine the current methodologies for detecting circRNAs and explore their diagnostic applications in IPF. Finally, we discuss the potential utility of circRNAs in the treatment of IPF. In conclusion, circRNAs hold great promise as novel biomarkers and therapeutic targets in the management of IPF.

Indexed as

Idiopathic Pulmonary FibrosisRNA, CircularBiomarkersHumansBiomarkersRNA, CircularAlveolar epitheliumCircular RNAFibroblastsIdiopathic pulmonary fibrosis

Identifiers

PMID38321530
PMCPMC10848557
OpenAlexW4391590512

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.