Trial reportCritical care (London, England)2024
Thiamine administration in septic shock: a post hoc analysis of two randomized trials.
Trial report in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thiamine as a Metabolic Resuscitator in Septic Shock
Thiamine as a Renal Protective Agent in Septic Shock: A Randomized, Controlled Study
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Mitochondrial dysfunction in sepsis: nutritional strategies for restoring bioenergetic homeostasis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review).International journal of molecular medicine · 2026Review
- Phenotype discovery and mortality prediction in sepsis-induced myocardial dysfunction: a deep learning and stratified modeling approach.BMC medical informatics and decision making · 2026Article
- Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials.Clinics (Sao Paulo, Brazil) · 2026Review
- Serum vitamins andFrontiers in immunology · 2026Observational
- The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications.Annals of intensive care · 2025Review
- The Role of Vitamins in Sepsis: A Narrative Review.Nutrients · 2025Review
- The Latest in Resuscitation Research: Highlights From the 2024 American Heart Association's Resuscitation Science Symposium.Journal of the American Heart Association · 2025Article
- [Focus on sepsis and general intensive care medicine 2024/2025 : Summary of selected intensive medical care studies].Die Anaesthesiologie · 2025Article
- Reframing Micronutrient Deficiencies for Modern times: A Review.Journal of general internal medicine · 2025Review
- Management of vasoplegic shock.BJA education · 2025Review
- Thiamine administration in septic shock: towards finding the target population.Critical care (London, England) · 2024Article
- Nutritional Strategies for the Treatment and Prevention of Sepsis Outside the Intensive Care Unit.Nutrients · 2024Review
- Benfotiamine improves dystrophic pathology and exercise capacity in mdx mice by reducing inflammation and fibrosis.Human molecular genetics · 2024Article
- Thiamine supplementation in septic shock patients: still looking for the target population.Critical care (London, England) · 2024Article
- Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study.Journal of anesthesia, analgesia and critical care · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.
methodsPatient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (NCT03550794) were combined in this analysis. The primary outcome for the current study was survival without the receipt of renal replacement therapy (RRT). Analyses were performed on the overall cohort and the thiamine-deficient cohort (thiamine < 8 nmol/L).
resultsTotally, 158 patients were included. Overall, thiamine administration was associated with higher odds of being alive and RRT-free (adjusted odds ratio [aOR]: 2.05 [95% confidence interval (CI) 1.08-3.90]) and not needing RRT (aOR: 2.59 [95% CI 1.01-6.62]). In the thiamine-deficient group, thiamine administration was associated with higher odds of being alive and RRT-free (aOR: 8.17 [95% CI 1.79-37.22]) and surviving to hospital discharge (aOR: 6.84 [95% CI 1.54-30.36]). There was a significant effect modification by baseline thiamine deficiency for alive and RRT-free (interaction, p = 0.016) and surviving to hospital discharge (p = 0.019).
conclusionIn the combined analysis of two previous randomized trials, thiamine administration was associated with higher odds of being alive and RRT-free at hospital discharge in patients with septic shock. This signal was stronger in patients with thiamine deficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.