Evidence map›Paper›PMID 38321515›Full record

ArticleJournal of anesthesia, analgesia and critical care2024

Assessment of seizure duration and utility of using SedLine

Houman Amirfarzan, Kaitlin Jane Cassidy, Mehrak Moaddab, Ma Demin, Roman Schumann, Bradford Lewis

Registry-linked trialAbstract read
In one paragraph

Article in Journal of anesthesia, analgesia and critical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07534839 (Evaluation of the Safety of Low-Flow Anesthesia Initiated Without Wash-in in Terms of Oxygenation and Depth of Anesthesia Using Arterial Blood Gas Analysis and EEG-Based PSI Monitoring), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07534839 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Safety of Low-Flow Anesthesia Initiated Without Wash-in in Terms of Oxygenation and Depth of Anesthesia Using Arterial Blood Gas Analysis and EEG-Based PSI Monitoring

TypeinterventionalSponsorErzincan Binali Yildirim UniversitesiRan2026 to 2026Enrolled60ConditionsLow Flow AnesthesiaArmsInitiation of low-flow anesthesia without wash-in following intubation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Houman AmirfarzanDepartment of Anesthesia, Critical Care and Pain Medicine, VA Boston Healthcare System, Tufts University School of Medicine, Boston, MA, USA. Houman.amirfarzan@va.gov.ORCID http://orcid.org/0000-0002-3843-2808
Kaitlin Jane CassidyCooperative Studies Program Clinical Trials Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.
Mehrak MoaddabDepartment of Anesthesia, Critical Care and Pain Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Ma DeminDepartment of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.
Roman SchumannDepartment of Anesthesia, Critical Care and Pain Medicine, VA Boston Healthcare System, Tufts University School of Medicine, Boston, MA, USA.
Bradford LewisDepartment of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectroconvulsive therapy (ECT) endures as a definitive treatment for refractory depression and catatonia and is also considered an effective treatment for a number of other severe psychiatric disorders (Lisanby, N Engl J Med 357:1939-1945, 2007)(Weiner and Prudic, Biol Psychiatry 73:105-106, 2013). GA is an essential component of the ECT procedure for various reasons (Lee, Jenkins and Sparkle, Life 11, 2021). Monitoring anesthetic effects on the brain is desirable as anesthetic agents affect seizure duration and recovery (Rasulo, Hopkins, Lobo, et al,  Neurocrit Care 38:296-311, 2023) (Jones , Nittur , Fleming and Applegate,  BMC Anesthesiol 21:105, 2021) (Soehle , Kayser , Ellerkmann and Schlaepfer,  BJA 112:695-702, 2013). Perioperative anesthetic effects on consciousness can be assessed with brain function monitoring using raw electroencephalogram (EEG) traces and processed EEG indices.

objectiveWe examined the usefulness and utility of the SedLine

methodsFollowing IRB approval, we analyzed the data of the electronic medical records of 45 ECT treatments of 23 patients in an urban VA medical center between July 01, 2021, and March 30, 2022. We compared the seizure duration in minutes and seconds as measured either by the ECT machine EEG tracing or the SedLine

resultsThere was no significant difference in measured seizure duration between the two methods examined (p < 0.05). We observed a lag of the SedLine PSI value at the time before stimulus delivery and limited PSI utility during the course of ECT.

conclusionThe SedLine

Indexed as

Anesthetic IVDepth of anesthesiaElectroconvulsive therapyMethohexitalProcessed EEGSedLine®

Identifiers

PMID38321515
PMCPMC10845389

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.