Evidence map›Paper›PMID 38321459›Full record

ArticleMalaria journal2024

Assessing availability, prices, and market share of quality-assured malaria ACT and RDT in the private retail sector in Nigeria and Uganda.

Meley Woldeghebriel, Ezinne Aso, Erica Berlin, Chizoba Fashanu, Sylvia N Kirumira, Felix Lam, Robert Mugerwa, Juliet Nakiganda, Tayo Olaleye, Jimmy Opigo and 8 more

Abstract read
In one paragraph

Article in Malaria journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

18 authors.

Meley WoldeghebrielClinton Health Access Initiative, Kampala, Uganda. mwoldeghebriel@clintonhealthaccess.org.
Ezinne AsoClinton Health Access Initiative, Abuja, Nigeria.
Erica BerlinClinton Health Access Initiative, Boston, Massachusetts, USA.
Chizoba FashanuClinton Health Access Initiative, Abuja, Nigeria.
Sylvia N KirumiraClinton Health Access Initiative, Kampala, Uganda.
Felix LamClinton Health Access Initiative, Boston, Massachusetts, USA.
Robert MugerwaNational Malaria Control Division, Ministry of Health, Kampala, Uganda.
Juliet NakigandaClinton Health Access Initiative, Kampala, Uganda.
Tayo OlaleyeClinton Health Access Initiative, Abuja, Nigeria.
Jimmy OpigoNational Malaria Control Division, Ministry of Health, Kampala, Uganda.
Funlola OsinupebiClinton Health Access Initiative, Abuja, Nigeria.
Natalie PriestleyClinton Health Access Initiative, Kampala, Uganda.
Rodger StringhamVirginia Commonwealth University, Richmond, Virginia, USA.
Perpetua UhomoibhiNational Malaria Elimination Programme, Abuja, Nigeria.
Theodoor VisserClinton Health Access Initiative, Boston, Massachusetts, USA.
Abigail WardClinton Health Access Initiative, Boston, Massachusetts, USA.
Owens WiwaClinton Health Access Initiative, Abuja, Nigeria.
Aaron WoolseyClinton Health Access Initiative, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn estimated 50% of suspected malaria cases in sub-Saharan Africa first seek care in the private sector, especially in private medicine retail outlets. Quality of care in these outlets is generally unknown but considered poor with many patients not receiving a confirmatory diagnosis or the recommended first-line artemisinin-based combination therapy (ACT). In 2010, a subsidy pilot scheme, the Affordable Medicines Facility malaria, was introduced to crowd out the use of monotherapies in favour of WHO-pre-qualified artemisinin-based combinations (WHO-PQ-ACTs) in the private health sector. The scheme improved the availability, market share, and cost of WHO-PQ-ACTs in countries like Nigeria and Uganda, but in 2018, the subsidies were halted in Nigeria and significantly reduced in Uganda. This paper presents findings from six retail audit surveys conducted from 2014 to 2021 in Nigeria and Uganda to assess whether the impact of subsidies on the price, availability, and market share of artemisinin-based combinations has been sustained after the subsidies were reduced or discontinued.

methodsSix independent retail audits were conducted in private medicine retail outlets, including pharmacies, drug shops, and clinics in Nigeria (2016, 2018, 2021), and Uganda (2014, 2019, 2020) to assess the availability, price, and market share of anti-malarials, including WHO-PQ-ACTs and non-WHO-PQ-ACTs, and malaria rapid diagnostic tests (RDTs).

resultsBetween 2016 and 2021, there was a 57% decrease in WHO-PQ-ACT availability in Nigeria and a 9% decrease in Uganda. During the same period, non-WHO-PQ-ACT availability increased in Nigeria by 41% and by 34% in Uganda. The price of WHO-PQ-ACTs increased by 42% in Nigeria to $0.68 and increased in Uganda by 24% to $0.95. The price of non-WHO-PQ-ACTs decreased in Nigeria by 26% to $1.08 and decreased in Uganda by 64% to $1.23. There was a 76% decrease in the market share of WHO-PQ-ACTs in Nigeria and a 17% decrease in Uganda. Malaria RDT availability remained low throughout.

conclusionWith the reduction or termination of subsidies for WHO-PQ-ACTs in Uganda and Nigeria, retail prices have increased, and retail prices of non-WHO-PQ-ACTs decreased, likely contributing to a shift of higher availability and increased use of non-WHO-PQ-ACTs.

Indexed as

AntimalarialsArtemisininsMalariaHumansNigeriaPrivate SectorUgandaAntimalarialsArtemisininsArtemisinin-based combination therapyClinicDrug shopPharmacyPrivate sector

Identifiers

PMID38321459
PMCPMC10848491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.