Evidence map›Paper›PMID 38321372›Full record

ArticleBMC neurology2024

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson's disease: a case-control study.

Peter George, Tamer Roushdy, Mai Fathy, Eman Hamid, Yosra Abdelzaher Ibrahim, Mahmoud El-Belkimy, Mohamed Ossama Abdulghani, Ali Shalash

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04308135 (The Clinical and Neuroimaging Differences Between Patients With Vascular Parkinsonism and Idiopathic Parkinson's Disease), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04308135 completednot on this map

The Clinical and Neuroimaging Differences Between Patients With Vascular Parkinsonism and Idiopathic Parkinson's Disease

TypeobservationalSponsorAin Shams UniversityRan2019 to 2022Enrolled104ConditionsVascular Parkinsonism, Parkinson's DiseaseArmsNeuro-radiological tools:, cognitive tests, lab investigations, Beck depression inventory (BDI)(Arabic version), Clinical Tools for Urinary symptoms:
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Vascular parkinsonism: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter GeorgeDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Tamer RoushdyDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mai FathyDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman HamidDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yosra Abdelzaher IbrahimDepartment of Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mahmoud El-BelkimyDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed Ossama AbdulghaniDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ali ShalashDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. ali_neuro@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) and vascular parkinsonism (VaP) have highly overlapping phenotypes, and different prognosis. This study comprehensively investigated the clinical, brain MRI and transcranial sonography differences between VaP and PD.

methodsForty-eight patients with PD, 27 patients with VaP, and 29 healthy controls were compared. All patients were assessed using the MDS-UPDRS, Berg Balance Scale (BBS), Ten-Meter Walking Test (10-MWT), Time Up and Go Test, and Non-Motor Symptoms Scale. Beck Depression Inventory, PD questionnaire- 39, international urine incontinence scale, cognitive assessment scales, MRI brain and transcranial colour-coded doppler. The study was registered on clinical-Trial.gov (NCT04308135) on 03/12/2020.

resultsVaP patients showed significantly older age of onset, shorter disease duration, lower drug doses and levodopa responsiveness, higher On and Off axial scores, On and Off BBS, higher On scores for PIGD, rigidity, bradykinesia and total motor MDS-UPDRS, lower On and Off tremor, lower-half predominance, lower asymmetrical presentation and symmetric index than PD patients. VaP patients had worse non-motor symptoms Scale (NMSS) than controls except for perceptual problems/hallucinations but better symptoms than PD patients except for urinary dysfunction. Quality of life (QoL) was impaired in VaP patients and was correlated with motor function and NMSs. The VaP group had significantly higher white matter lesions and brain atrophy, with lower hyperechogenicity of the substantia nigra and more impaired cerebral vascular resistance and vasoreactivity than the PD group.

conclusionsVaP has a characteristic motor and non-motor profile, with impaired QoL, white matter, and transcranial sonography abnormalities that differentiate it from PD. Further studies are warranted to explore the role of vascular lesions in the pathogenesis of VaP.

trial registrationThe registered identifier NCT04308135 on clinical-Trial.gov. Registered on 03/12/2020.

Indexed as

Parkinson DiseaseCase-Control StudiesHumansPostural BalanceQuality of LifeTime and Motion StudiesUltrasonography, Doppler, TranscranialBrain MRINon-motorParkinson’s diseaseQuality of lifeTCCDVascular parkinsonism

Identifiers

PMID38321372
PMCPMC10845551

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.