ArticleNature neuroscience2024
Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cerebellum-inspired neural network of supervised learning with tensor-based sparse coding for multi-class classification.PLoS computational biology · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination.Experimental & molecular medicine · 2026Article
- How does the cerebellum contribute to cognitive functions?PLoS biology · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys.bioRxiv : the preprint server for biology · 2025Article
- GlyT2-Positive Interneurons Regulate Timing and Variability of Information Transfer in a Cerebellar-Behavioral Loop.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Balance Performance in Aged Mice is Dependent on Unipolar Brush Cells.Cerebellum (London, England) · 2024Article
- Balance performance in aged mice is dependent on unipolar brush cells.bioRxiv : the preprint server for biology · 2024Article
- DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity.Nature methods · 2024Article
- Review
- Sensory encoding and memory in the mushroom body: signals, noise, and variability.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Article
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4 authors.
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Abstract
The cerebellar cortex has a key role in generating predictive sensorimotor associations. To do so, the granule cell layer is thought to establish unique sensorimotor representations for learning. However, how this is achieved and how granule cell population responses contribute to behavior have remained unclear. To address these questions, we have used in vivo calcium imaging and granule cell-specific pharmacological manipulation of synaptic inhibition in awake, behaving mice. These experiments indicate that inhibition sparsens and thresholds sensory responses, limiting overlap between sensory ensembles and preventing spiking in many granule cells that receive excitatory input. Moreover, inhibition can be recruited in a stimulus-specific manner to powerfully decorrelate multisensory ensembles. Consistent with these results, granule cell inhibition is required for accurate cerebellum-dependent sensorimotor behavior. These data thus reveal key mechanisms for granule cell layer pattern separation beyond those envisioned by classical models.
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