Evidence map›Paper›PMID 38321256›Full record

ArticleScientific reports2024

Green cocoon-derived sericin reduces cellular damage caused by radiation in human keratinocytes.

Nahoko Kakihara, Momoko Sato, Ayaki Shirai, Mizuki Koguchi, Shiori Yamauchi, Toshimichi Nakano, Ryuta Sasamoto, Hideyo Sato

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nahoko KakiharaDepartment of Nursing, Graduate School of Health Sciences, Niigata University, Niigata, Japan. kakihara@clg.niigata-u.ac.jp.
Momoko SatoDepartment of Medical Technology, Faculty of Medicine, Niigata University, Niigata, Japan.
Ayaki ShiraiDepartment of Medical Technology, Faculty of Medicine, Niigata University, Niigata, Japan.
Mizuki KoguchiDepartment of Medical Technology, Faculty of Medicine, Niigata University, Niigata, Japan.
Shiori YamauchiDepartment of Medical Technology, Faculty of Medicine, Niigata University, Niigata, Japan.
Toshimichi NakanoDepartment of Radiology and Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Ryuta SasamotoDepartment of Radiological Technology, Graduate School of Health Sciences, Niigata University, Niigata, Japan.
Hideyo SatoDepartment of Medical Technology, Faculty of Medicine, Niigata University, Niigata, Japan.

Funding

JSPS KAKENHI 22H03385
6 · The paper itself

Abstract

Radiation therapy used in the treatment of cancer causes skin damage, and no method of care has been established thus far. Recently, it has become clear that sericin derived from silkworm cocoons has moisturizing and antioxidant functions. In addition, green cocoon-derived sericin, which is rich in flavonoids, may have enhanced functions. However, whether this green cocoon-derived sericin can reduce radiotherapy-induced skin damage is unclear. In the present study, we aimed at establishing care methods to reduce skin cell damage caused by X-irradiation using green cocoon-derived sericin. We investigated its effect on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction. Our results showed that green cocoon-derived sericin reduced cell damage caused by X-irradiation. However, this effect was not observed when cells were treated before X-irradiation or with a sericin derived from white cocoons. In addition, green cocoon-derived sericin decreased the levels of reactive oxygen species and lipid peroxidation. Our results suggest that green cocoon sericin mitigates the damaging effect of X-irradiation on cells, hence presenting potential usefulness in reducing skin damage from radiation therapy and opening new avenues in the care of cancer patients.

Indexed as

BombyxSericinsAnimalsAntioxidantsHumansKeratinocytesSilkSkinAntioxidantsSericinsSilk

Identifiers

PMID38321256
PMCPMC10847496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.