Evidence map›Paper›PMID 38321223›Full record

ArticleCardiovascular and interventional radiology2024

Factors Impacting Survival After Transarterial Radioembolization in Patients with Unresectable Intrahepatic Cholangiocarcinoma: A Combined Analysis of the Prospective CIRT Studies.

Peter Reimer, Valérie Vilgrain, Dirk Arnold, Tugsan Balli, Rita Golfieri, Romaric Loffroy, Cristina Mosconi, Maxime Ronot, Christian Sengel, Niklaus Schaefer and 9 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02305459 completednot on this map

CIRSE Registry for SIR-Spheres Therapy

Typeobservational_patient_registrySponsorCardiovascular and Interventional Radiological Society of EuropeRan2014 to 2020Enrolled1,051ConditionsLiver CarcinomaArmsYttrium-90 loaded SIR-Spheres microspheres, QLQ-C30 with HCC module
NCT03256994 completednot on this map

CIRSE Registry for SIR-Spheres in France (CIRT-FR)

Typeobservational_patient_registrySponsorCardiovascular and Interventional Radiological Society of EuropeRan2017 to 2022Enrolled332ConditionsLiver CancerArmsYttrium-90 loaded SIR-Spheres microspheres, QLQ-C30 with HCC module
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Radiological Loco-Regional Treatments for Cholangiocarcinoma: A Systematic Review of the Literature.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 9 countries.

Peter ReimerStädtisches Klinikum Karlsruhe, Institute for Diagnostic and Interventional Radiology, Academic Teaching Hospital the University of Freiburg, Moltkestraße 90, 76133, Karlsruhe, Germany.
Valérie VilgrainUniversité Paris Cité, CRI, INSERM, 1149, Paris, France.
Dirk ArnoldOncology and Hematology, Asklepios Tumorzentrum Hamburg, AK Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Germany.
Tugsan BalliRadiology Department, Çukurova University, Balcalı Hospital, 01330, Adana, Turkey.
Rita GolfieriDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Romaric LoffroyDepartment of Vascular and Interventional Radiology, Image-Guided Therapy Center, CHU Dijon Bourgogne, François-Mitterrand University Hospital, 14 Rue Gaffarel, 21000, Dijon, France.
Cristina MosconiDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Maxime RonotUniversité Paris Cité, CRI, INSERM, 1149, Paris, France.
Christian SengelInterventional Radiology, Centre Hospitalier Universitaire de Grenoble, Boulevard de La Chantourne, 38100, Grenoble, France.
Niklaus SchaeferService de Médecine Nucléaire Et Imagerie Moléculaire, CHUV, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Geert MaleuxRadiology, Universitair Ziekenhuis Leuven, Herestraat 49, 3000, Leuven, Belgium.
Graham MunnekeInterventional Oncology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London, NW1 2PG, UK.
Bora PeynirciogluDepartment of Radiology, School of Medicine, Hacettepe University, Sihhiye Campus, 06100, Ankara, Turkey.
Bruno SangroLiver Unit and HPB Oncology Area, Clínica Universidad de Navarra and CIBEREHD, Avda. Pio XII 36, 31008, Pamplona, Spain.
Nathalie KaufmannClinical Research Department, Cardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9, 1010, Vienna, Austria.
Maria UrdanizClinical Research Department, Cardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9, 1010, Vienna, Austria.
Helena PereiraAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Unité de Recherche Clinique, Paris, France.
Niels de JongClinical Research Department, Cardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9, 1010, Vienna, Austria. dejong@cirse.org.ORCID http://orcid.org/0000-0002-2377-2973
Thomas HelmbergerDepartment of Radiology, Neuroradiology and Minimal-Invasive Therapy, Klinikum Bogenhausen, Englschalkinger Str. 77, 81925, Munich, Germany.
Cardiovascular and Interventional Radiological Society of Europe · ATInserm · FRAzienda USL di Bologna · ITAsklepios Klinik Altona · DECentre Hospitalier Universitaire de Grenoble · FRCentro de Investigación Biomédica en Red · ESCukurova University · TRHacettepe University · TRMünchen Klinik Bogenhausen · DEStädtisches Klinikum Karlsruhe · DEUniversitair Ziekenhuis Leuven · BEUniversity College London Hospitals NHS Foundation Trust · GBUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTransarterial radioembolization (TARE) with Yttrium-90 resin microspheres is a treatment option for patients with intrahepatic cholangiocarcinoma (ICC). However, optimising the timing of TARE in relation to systemic therapies and patient selection remains challenging. We report here on the effectiveness, safety, and prognostic factors associated with TARE for ICC in a combined analysis of the prospective observational CIRT studies (NCT02305459 and NCT03256994).

methodsA combined analysis of 174 unresectable ICC patients enrolled between 2015 and 2020 was performed. Patient characteristics and treatment-related data were collected at baseline; adverse events and time-to-event data (overall survival [OS], progression-free survival [PFS] and hepatic PFS) were collected at every follow-up visit. Log-rank tests and a multivariable Cox proportional hazard model were used to identify prognostic factors.

resultsPatients receiving a first-line strategy of TARE in addition to any systemic treatment had a median OS and PFS of 32.5 months and 11.3 months. Patients selected for first-line TARE alone showed a median OS and PFS of 16.2 months and 7.4 months, whereas TARE as 2nd or further treatment-line resulted in a median OS and PFS of 12 and 9.3 months (p = 0.0028), and 5.1 and 3.5 months (p = 0.0012), respectively. Partition model dosimetry was an independent predictor for better OS (HR 0.59 [95% CI 0.37-0.94], p = 0.0259). No extrahepatic disease, no ascites, and < 6.1 months from diagnosis to treatment were independent predictors for longer PFS.

conclusionThis combined analysis indicates that in unresectable ICC, TARE in combination with any systemic treatment is a promising treatment option. LEVEL OF EVIDENCE: level 3, Prospective observational.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaEmbolization, TherapeuticLiver NeoplasmsBile Ducts, IntrahepaticHumansObservational Studies as TopicProspective StudiesRetrospective StudiesYttrium RadioisotopesYttrium RadioisotopesIntrahepatic cholangiocarcinomaLiverObservationalRegistriesSelective internal radiation therapyTransarterial radioembolization

Identifiers

PMID38321223
PMCPMC10920466
OpenAlexW4391578763

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.