Evidence map›Paper›PMID 38320993›Full record

SynthesisTranslational psychiatry2024

Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population.

Kyungtaek Park, Ah Ra Do, Yuree Chung, Min Ji Kim, Sang Jin Rhee, Dae Hyun Yoon, Seung Ho Choi, Sung Joon Cho, Han-Na Kim, Yong Min Ahn and 1 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyungtaek ParkInstitute of Health and Environment, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0003-0786-6969
Ah Ra DoInterdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Yuree ChungDepartment of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0003-4637-9223
Min Ji KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Sang Jin RheeDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-6221-5953
Dae Hyun YoonDepartment of Psychiatry, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.ORCID 0000-0003-4724-5980
Seung Ho ChoiDepartment of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.
Sung Joon ChoDepartment of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Han-Na KimDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea. hanna147942@gmail.com.ORCID 0000-0001-7053-7469
Yong Min AhnDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. aym@snu.ac.kr.ORCID 0000-0002-4458-797X
Sungho WonInstitute of Health and Environment, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr.ORCID 0000-0001-5751-5089

Funding

Ministry of Trade, Industry and Energy (Ministry of Trade, Industry and Energy, Korea) 20000134
6 · The paper itself

Abstract

Although depression is an emerging disorder affecting many people worldwide, most genetic studies have been performed in European descent populations. Herein, a genome-wide association study (GWAS) was conducted in Korean population to elucidate the genomic loci associated with depressive symptoms. Two independent cohorts were used as discovery datasets, which consisted of 6474 (1484 cases and 4990 controls) and 1654 (557 cases and 1097 controls) Korean participants, respectively. The participants were divided into case and control groups based on the Beck Depression Inventory (BDI). Meta-analysis using the two cohorts revealed that rs6945590 was significantly associated with the risk of depressive symptoms [P = 2.83 × 10

Indexed as

DepressionGenome-Wide Association StudyGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideRepublic of KoreaThromboxane-A SynthaseThromboxane-A Synthase

Identifiers

PMID38320993
PMCPMC10847124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.