ArticleNature communications2024
The impact of reproductive factors on the metabolic profile of females from menarche to menopause.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses.Systematic reviews · 2026Pooled it
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women.npj aging · 2026Article
- Age at Menarche, Cardiometabolic Disease Prevalence, and Disease Control in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey.International journal of medical sciences · 2026Article
- The relationship between polyunsaturated fatty acids and inflammation: evidence from cohort and Mendelian randomization analyses.International journal of epidemiology · 2025Article
- Higher blood lipid levels after the transition to menopause in two forager-horticulturalist populations.Evolution, medicine, and public health · 2025Article
- Optimal waist circumference cut-off points for predicting metabolic syndrome among females of reproductive age in Wakiso district, central Uganda.PLOS global public health · 2025Article
- Dissecting the shared genetic architecture between anti-Müllerian hormone and age at menopause based on genome-wide association study.American journal of obstetrics and gynecology · 2024Article
- Article
- Sex-Specific Variation in Metabolic Responses to Diet.Nutrients · 2024Review
- Contributions of white adipose tissue to energy requirements for female reproduction.Trends in endocrinology and metabolism: TEM · 2024Review
- Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity.Biomedicines · 2024Review
- Identifying metabolic features of colorectal cancer liability using Mendelian randomization.eLife · 2023Article
- Identifying metabolic features of colorectal cancer liability using Mendelian randomization.medRxiv : the preprint server for health sciences · 2023Article
- Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses.Journal of affective disorders · 2023Article
- Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight.Metabolites · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We explore the relation between age at menarche, parity and age at natural menopause with 249 metabolic traits in over 65,000 UK Biobank women using multivariable regression, Mendelian randomization and negative control (parity only). Older age of menarche is related to a less atherogenic metabolic profile in multivariable regression and Mendelian randomization, which is largely attenuated when accounting for adult body mass index. In multivariable regression, higher parity relates to more particles and lipids in VLDL, which are not observed in male negative controls. In multivariable regression and Mendelian randomization, older age at natural menopause is related to lower concentrations of inflammation markers, but we observe inconsistent results for LDL-related traits due to chronological age-specific effects. For example, older age at menopause is related to lower LDL-cholesterol in younger women but slightly higher in older women. Our findings support a role of reproductive traits on later life metabolic profile and provide insights into identifying novel markers for the prevention of adverse cardiometabolic outcomes in women.
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Registered trials
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