ArticleAmerican journal of human genetics2024
Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Article in American journal of human genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Multi-ancestry modeling improves fine-mapping resolution, protein prediction, and discovery for proteome-wide association studies.medRxiv : the preprint server for health sciences · 2026Article
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.Research square · 2026Article
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.medRxiv : the preprint server for health sciences · 2026Article
- Minimal correlation but complementary diagnostic utility for plasma cell-free RNA and proteins.Communications medicine · 2026Article
- Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer.BMC cancer · 2025Article
- Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects.Nature communications · 2025Article
- Genomic and GEO data integration identifies PDGFB as a potential therapeutic target for sepsis.Scientific reports · 2025Article
- Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease.American journal of human genetics · 2025Article
- Uncovering causal gene-tissue pairs and variants: A multivariable TWAS method controlling for infinitesimal effects.medRxiv : the preprint server for health sciences · 2024Article
- Uncovering causal gene-tissue pairs and variants: A multivariable TWAS method controlling for infinitesimal effects.Research square · 2024Article
- Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns.BMC genomics · 2024Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 1 country.
Funding
Abstract
Regulation of transcription and translation are mechanisms through which genetic variants affect complex traits. Expression quantitative trait locus (eQTL) studies have been more successful at identifying cis-eQTL (within 1 Mb of the transcription start site) than trans-eQTL. Here, we tested the cis component of gene expression for association with observed plasma protein levels to identify cis- and trans-acting genes that regulate protein levels. We used transcriptome prediction models from 49 Genotype-Tissue Expression (GTEx) Project tissues to predict the cis component of gene expression and tested the predicted expression of every gene in every tissue for association with the observed abundance of 3,622 plasma proteins measured in 3,301 individuals from the INTERVAL study. We tested significant results for replication in 971 individuals from the Trans-omics for Precision Medicine (TOPMed) Multi-Ethnic Study of Atherosclerosis (MESA). We found 1,168 and 1,210 cis- and trans-acting associations that replicated in TOPMed (FDR < 0.05) with a median expected true positive rate (π
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.