Evidence map›Paper›PMID 38320540›Full record

ArticleEuropean neurology2024

Causal Relationship between Parkinson's Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study.

Lize Chen, Qiushi Zhang, Shiduo Li, Haoran Chen, Jing Guo, Zongmao Zhao, Jing Tong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lize ChenDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China, chenlize0@163.com.
Qiushi ZhangDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Shiduo LiDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Haoran ChenDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jing GuoDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zongmao ZhaoDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jing TongDepartment of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Fourth Hospital of Hebei Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to investigate the causal relationship between Parkinson's disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis.

methodsBy using data from publicly available genome-wide association studies from databases, single nucleotide polymorphisms were screened as instrumental variables, and the MR analysis was finished by inverse-variance weighted (IVW), MR-egger, weighted median methods.

resultsThe primary IVW method showed a negative association between genetically predicted PD and risk of MI (OR = 0.9989; 95% CI: 0.9980-0.9998; p = 0.02). However, PD was not significantly associated with AF or VTE.

conclusionThis study suggests a negative association between PD with MI, which implies that PD has a protective effect on MI.

Indexed as

Parkinson DiseaseVascular DiseasesVenous ThromboembolismGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideCausalityMendelian randomization analysisMyocardial infarctionParkinson’s diseaseVenous thromboembolism

Identifiers

PMID38320540
PMCPMC10997265
OpenAlexW4392390894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.