Evidence map›Paper›PMID 38320522›Full record

ArticleDevelopmental neuroscience2024

Central Autonomic Network and Heart Rate Variability in Premature Neonates.

Kelsey Christoffel, Josepheen De Asis-Cruz, Rathinaswamy B Govindan, Jung Hoon Kim, Kevin Michael Cook, Kushal Kapse, Nickie Andescavage, Sudeepta Basu, Emma Spoehr, Catherine Limperopoulos and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kelsey ChristoffelDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA, kchristoff@childrensnational.org.
Josepheen De Asis-CruzDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Rathinaswamy B GovindanPrenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA.
Jung Hoon KimDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Kevin Michael CookDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Kushal KapseDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Nickie AndescavageDivision of Neonatology, Children's National Hospital, Washington, District of Columbia, USA.
Sudeepta BasuDivision of Neonatology, Children's National Hospital, Washington, District of Columbia, USA.
Emma SpoehrDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Catherine LimperopoulosDeveloping Brain Institute, Children's National Hospital, Washington, District of Columbia, USA.
Adre du PlessisPrenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA.

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Impaired Brain Development in a Premature Ex-utero EnvironmentR01HD099393 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$3.4M
Diversity Supplement: Clinical Pediatric Research Training for the Fetal-Neonatal BrainT32HD098066 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$1.7M
NICHD NIH HHS R01 HD099393NICHD NIH HHS T32 HD098066NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

introductionThe Central Autonomic Network (CAN) is a hierarchy of brain structures that collectively influence cardiac autonomic input, mediating the majority of brain-heart interactions, but has never been studied in premature neonates. In this study, we use heart rate variability (HRV), which has been described as the "primary output" of the CAN, and resting-state functional MRI (rsfMRI) to characterize brain-heart relationships in premature neonates.

methodsWe studied premature neonates who underwent rsfMRI at term (37-week postmenstrual age or above) and had HRV data recorded during the same week of their MRI. HRV was derived from continuous electrocardiogram data during the week of the rsfMRI scan. For rsfMRI, a seed-based approach was used to define regions of interest (ROIs) pertinent to the CAN, and blood oxygen level-dependent signal was correlated between each ROI as a measure of functional connectivity. HRV was correlated with CAN connectivity (CANconn) for each region, and subgroup analysis was performed based on sex and clinical comorbidities.

resultsForty-seven premature neonates were included in this study, with a mean gestational age at birth of 28.1 +/- 2.6 weeks. Term CANconn was found to be significantly correlated with HRV in approximately one-fifth of CAN connections. Two distinct patterns emerged among these HRV-CANconn relationships. In the first, increased HRV was associated with stronger CANconn of limbic regions. In the second pattern, stronger CANconn at the precuneus was associated with impaired HRV maturation. These patterns were especially pronounced in male premature neonates.

conclusionWe report for the first time evidence of brain-heart relationships in premature neonates and an emerging CAN, most striking in male neonates, suggesting that the brain-heart axis may be more vulnerable in male premature neonates. Signatures in the heart rate may eventually become an important noninvasive tool to identify premature males at highest risk for neurodevelopmental impairment.

Indexed as

Autonomic Nervous SystemBrainHeart RateInfant, PrematureMagnetic Resonance ImagingElectrocardiographyFemaleHumansInfant, NewbornMaleNerve NetAutonomic nervous systemConnectivityDeveloping brainHeart rate variabilityNeonatal period

Identifiers

PMID38320522
PMCPMC11300706

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.